Increased saliva cotinine concentrations in smokers during rapid weight loss.
Increased saliva cotinine concentrations in smokers during rapid weight loss.
复制标题
吸烟者在快速减肥期间唾液可替宁浓度增加。
DOI：
10.1037//0022-006x.60.6.985
复制
发表时间：
1992
影响因子：
5.9
通讯作者：
Abrams,DB
中科院分区：
文献类型：
--
作者：
Niaura,R;Clark,MM;Raciti,MA;Pera,V;Abrams,DB
虽然戒烟对体重增加的影响是有据可查的，但人们对减肥对吸烟的影响知之甚少。我们研究了一组9名肥胖女性吸烟者在参加蛋白质节约改良禁食（Optifast）期间唾液可替宁水平与体重减轻之间的关系。在治疗的前3个月，受试者只食用保留蛋白质的补充剂；在接下来的3个月里，食物逐渐被重新引入。在研究开始时、3个月和6个月时评估体重指数和唾液可替宁浓度。在3个月和6个月时，体重明显减轻，但可替宁水平在此期间显著增加。目前尚不清楚可替宁的增加是由于代谢变化还是尼古丁摄入量的实际增加。研究结果表明，在体重显著减轻期间，与吸烟相关的健康风险可能会增加。
Although the effect of smoking cessation on weight gain is well-documented, little is known about the effect of weight loss on smoking. We examined the association between saliva cotinine levels and weight loss in a group of 9 obese female smokers during participation in a protein-sparing modified fast (Optifast). For the first 3 months of treatment, subjects consumed only the protein-sparing supplement; for the next 3 months, food was gradually reintroduced. Body mass index and saliva cotinine concentration were assessed at study entry and at 3 and 6 months. A significant weight loss was noted at 3 and 6 months, yet the cotinine level increased significantly over this time. It is unclear whether the cotinine increase is due to metabolic changes or an actual increase in nicotine intake. The results suggest that smoking-related health risks may increase during periods of significant weight loss.