Potential Medications or Compounds Acting on Toll-like Receptors in Cerebral Ischemia.
Potential Medications or Compounds Acting on Toll-like Receptors in Cerebral Ischemia.
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DOI：
10.2174/1570159x15666170601125139
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发表时间：
2018-01-30
影响因子：
5.3
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Li M;Liu J;Bi Y;Chen J;Zhao L
toll样受体在缺血性损伤后的炎症反应过程中起着不可或缺的作用。作用于tlr的治疗潜力值得评估。本文的目的是向读者介绍一些可能通过tlr减轻缺血性损伤的药物或化合物。综述了网上有关tlr的研究文章。分类如下：直接作用于TLR的方法，MyD88或TRIF信号通路的调节，TLR配体预处理或后适应或TLR作用引起的脑缺血耐受。关于直接影响的研究很少。抗tlr4或抗tlr2治疗可能是治疗急性事件的有希望的策略。以抑制NF-κB信号通路和增强干扰素调节因子依赖性信号通路为目标的研究引起了人们的极大兴趣。不仅是药物，中药提取物对脑缺血的神经保护作用也已被证实。此外，许多研究者报道了TLR2、3、4、7和9激动剂预处理的积极治疗效果。一些试验也探索了后处理的潜力，为缺血性治疗提供了新的思路。综上所述，许多药物和新化合物可能具有减少缺血性损伤的巨大潜力。本文将重点介绍利用tlr对缺血性损伤发挥神经保护作用的治疗方法。
Toll-like receptors play an integral role in the process of inflammatory response after ischemic in-jury. The therapeutic potential acting on TLRs is worth of evaluations. The aim of this review was to introduce readers some potential medications or compounds which could alleviate the ischemic damage via TLRs. Research articles online on TLRs were reviewed. Categorizations were listed according to the follows, methods acting on TLRs directly, modulations of MyD88 or TRIF signaling pathway, and the ischemic tolerance induced by the pre-conditioning or postconditioning with TLR ligands or minor cerebral ischemia via acting on TLRs. There are only a few studies concerning on direct effects. Anti-TLR4 or anti-TLR2 therapies may serve as promis-ing strategies in acute events. Approaches targeting on inhibiting NF-κB signaling pathway and enhancing interferon regu-latory factor dependent signaling have attracted great interests. Not only drugs but compounds extracted from traditional Chinese medicine have been used to identify their neuroprotective effects against cerebral ischemia. In addition, many re-searchers have reported the positive therapeutic effects of preconditioning with agonists of TLR2, 3, 4, 7 and 9. Several trails have also explored the potential of postconditioning, which provide a new idea in ischemic treatments. Considering all the evidence above, many drugs and new compounds may have great potential to reduce ischemic insults. This review will focus on promising therapies which exerting neuroprotective effects against ischemic injury by acting on TLRs.