Lymphatic Vessel Network Structure and Physiology
Lymphatic Vessel Network Structure and Physiology
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DOI：
10.1002/cphy.c180015
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发表时间：
2019-01-01
影响因子：
5.8
通讯作者：
Murfee, Walter L.
中科院分区：
文献类型：
--
作者：
Breslin, Jerome W.;Yang, Ying;Murfee, Walter L.
淋巴系统由与淋巴组织相关的血管网络组成，其整体功能是维持身体所有组织中每个细胞的局部生理环境。淋巴系统维持细胞外液稳态，有利于最佳组织功能，清除由于代谢或细胞死亡而产生的物质，并优化对细菌，病毒，寄生虫和其他抗原的免疫力。本文提供了一个全面的审查，在过去的一个世纪的重要发现沿着随着最近的进展，在了解淋巴管的解剖和生理学，包括组织/器官特异性，发展，淋巴形成和运输的机制，淋巴管生成，以及在疾病中的作用的淋巴管。(c)2019美国生理学会
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease. (c) 2019 American Physiological Society.