A Functionally Guided Approach to the Morphometry of Occipitotemporal Regions in Developmental Dyslexia: Evidence for Differential Effects in Boys and Girls
A Functionally Guided Approach to the Morphometry of Occipitotemporal Regions in Developmental Dyslexia: Evidence for Differential Effects in Boys and Girls
复制标题
DOI：
10.1523/jneurosci.5854-12.2013
复制
发表时间：
2013-07-03
影响因子：
5.3
通讯作者：
Dehaene-Lambertz, Ghislaine
中科院分区：
文献类型：
--
作者：
Altarelli, Irene;Monzalvo, Karla;Dehaene-Lambertz, Ghislaine
发展性阅读障碍是一种特别影响阅读习得的学习障碍。据报道，与对照组相比，阅读障碍受试者在各个颞叶区域的皮质异常和灰质体积差异。然而，研究之间缺乏一致性。在本实验中，我们集中我们的结构分析腹侧枕颞区，定义其功能的视觉类别的反应。我们采用了一个主题的主题功能指导的方法，共76名参与者（31名诵读困难儿童）。皮质厚度估计每个参与者周围的特定功能激活视觉文字，面孔，或地方的高峰。来自两个独立数据集的结果显示，与对照组相比，睡眠障碍儿童左半球对文字反应区域的厚度减少。此外，由于仅女孩存在差异，在同一地点观察到性别与诊断的相互作用。为了避免阅读水平的潜在混淆，我们还对比了在阅读表现方面匹配的阅读障碍儿童和对照儿童，我们观察到了类似的差异，尽管在较小范围的皮层。因此，本研究提供了一个局灶性皮层厚度减少阅读障碍的腹侧枕颞叶皮层的子区域，专门响应视觉文字，当年龄，性别和阅读性能考虑在内的第一个帐户。
Developmental dyslexia is a learning disability that specifically affects reading acquisition. Cortical anomalies and gray matter volume differences in various temporal regions have been reported in dyslexic subjects compared with controls. However, consistency between studies is lacking. In the present experiments, we focused our structural analyses on the ventral occipitotemporal regions, defined by their functional response to visual categories. We applied a subject-by-subject functionally guided approach on a total of 76 participants (31 dyslexic children). Cortical thickness was estimated for each participant around his/her peak of specific functional activation to visual words, faces, or places. Results from two independent datasets showed a reduction in thickness in dyslexic children compared with controls in the region responsive to words, in the left hemisphere. Additionally, a gender-by-diagnosis interaction was observed at the same location, due to differences in girls only. To avoid the potential confound of reading level, we also contrasted dyslexic and control children matched for reading performance, and we observed a similar difference, although in a smaller extent of cortex. The present study thus provides the first account of a focal cortical thickness reduction in dyslexia in the subregion of ventral occipitotemporal cortex specifically responsive to visual words, when age, gender, and reading performance are taken into account.