Functional Diversity of Subicular Principal Cells during Hippocampal Ripples
Functional Diversity of Subicular Principal Cells during Hippocampal Ripples
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DOI：
10.1523/jneurosci.5034-14.2015
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发表时间：
2015-10-07
影响因子：
5.3
通讯作者：
Schmitz, Dietmar
中科院分区：
文献类型：
--
作者：
Boehm, Claudia;Peng, Yangfan;Schmitz, Dietmar
皮质和海马振荡在记忆的编码、巩固和检索中起着至关重要的作用。与锐波相关的波纹已被证明对于巩固记忆是必要的。在巩固过程中，信息从海马体转移到新皮质。海马体和新皮质之间界面的结构之一是下托。因此，它非常适合调解从海马体到其他区域的信息传输和分发。通过对清醒小鼠的近细胞和全细胞记录，我们在此表明，在下托中，锥体细胞的一个子集被激活，而另一个子集在波纹期间被抑制。我们证明这些功能不同的亚群是由它们的细胞亚型预先确定的。突发单元有选择地用于在波动期间传输信息，而常规发射单元的发射概率会降低。通过体外多个膜片钳记录，我们表明细胞亚型特异性差异延伸到本地网络拓扑。这反映在不对称布线方案中，其中突发单元和常规发射单元在它们之间循环连接，但子类型之间的连接仅存在于常规单元到突发单元。此外，正常放电细胞上的抑制连接比爆发细胞上的抑制连接更多。我们得出的结论是，网络拓扑有助于在尖波相关波纹期间观察到的下锥体细胞的功能多样性。
Cortical and hippocampal oscillations play a crucial role in the encoding, consolidation, and retrieval of memory. Sharp-wave associated ripples have been shown to be necessary for the consolidation of memory. During consolidation, information is transferred from the hippocampus to the neocortex. One of the structures at the interface between hippocampus and neocortex is the subiculum. It is therefore well suited to mediate the transfer and distribution of information from the hippocampus to other areas. By juxtacellular and whole-cell-recordings in awake mice, we show here that in the subiculum a subset of pyramidal cells is activated, whereas another subset is inhibited during ripples. We demonstrate that these functionally different subgroups are predetermined by their cell subtype. Bursting cells are selectively used to transmit information during ripples, whereas the firing probability in regular firing cells is reduced. With multiple patch-clamp recordings in vitro, we show that the cell subtype-specific differences extend into the local network topology. This is reflected in an asymmetric wiring scheme where bursting cells and regular firing cells are recurrently connected among themselves but connections between subtypes exclusively exist from regular to bursting cells. Furthermore, inhibitory connections are more numerous onto regular firing cells than onto bursting cells. We conclude that the network topology contributes to the observed functional diversity of subicular pyramidal cells during sharp-wave associated ripples.