ANALYSIS OF DOUBLE-SUBSTRATE LIMITED GROWTH
ANALYSIS OF DOUBLE-SUBSTRATE LIMITED GROWTH
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DOI：
10.1002/bit.260200203
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发表时间：
1978-01-01
影响因子：
3.8
通讯作者：
BADER, FG
中科院分区：
文献类型：
--
作者：
BADER, FG
将微生物的生长速度与单一的极限底物浓度联系起来的数学模型早已建立。近年来，很明显，在某些条件下，生物体的生长速度可能同时受到2种或更多底物的限制。双底物限制的数学模型分为两类：交互模型和非交互模型。从概念和数学的角度对这两种模型进行了讨论。提出了一种需要2种不同底物才能产生单一产物的酶的类似情况。这种酶模拟物表明，两种类型的双底物限制模型在一定条件下似乎是可行的。基于化学计量学和比生长率-底物浓度等高线图，提出了一种确定双底物限制操作条件的方法。
Mathematical models which relate the growth rate of a microorganism to a single limiting substrate concentration were long established. In recent years, it became apparent that, under certain conditions, the growth rate of an organism may be simultaneously limited by 2 or more substrates. Mathematical models of double-substrate limitation fall into 2 categories: interactive and noninteractive models. A discussion of both types of models is presented in both conceptual and mathematical terms. An analogous case of an enzyme which requires 2 different substrates to produce a single product is presented. This enzyme analog indicates that both types of double-substrate limitation models appear to be feasible under certain conditions. Based upon stoichiometry and specific growth rate-substrate concentration contour plots, a method for determining the operational conditions which will lead to double-substrate limitation is presented.