Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis.
Recent Advances in Nanomedicine for the Diagnosis and Therapy of Liver Fibrosis.
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纳米医学诊断和治疗肝纤维化的最新进展
DOI：
10.3390/nano10101945
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发表时间：
2020-09-29
期刊：
影响因子：
--
通讯作者：
Zhai S
中科院分区：
文献类型：
--
作者：
Bai X;Su G;Zhai S
肝纤维化是由慢性肝损伤引起的炎症和纤维沉积的可逆病理过程，可引起严重的健康并发症，包括肝功能衰竭、肝硬化和肝癌。传统的诊断方法和基于药物的治疗存在一些局限性，如缺乏准确性和治疗效率不足。纳米医学作为纳米技术的一种医学应用，在肝纤维化的诊断和治疗方面显示出巨大的潜力。纳米医学增强成像对比度，改善组织渗透和细胞内化；它同时实现靶向给药、联合治疗以及诊断和治疗（即治疗学）。在这篇综述中，介绍了用于肝纤维化诊断、治疗和治疗的纳米医学系统的最新设计和开发工作。与传统方法相比，这些纳米药物系统在肝纤维化治疗方面普遍表现出显著的改善。这些纳米医学系统从实验室转化为临床使用的观点和挑战也进行了讨论。
Liver fibrosis, a reversible pathological process of inflammation and fiber deposition caused by chronic liver injury and can cause severe health complications, including liver failure, liver cirrhosis, and liver cancer. Traditional diagnostic methods and drug-based therapy have several limitations, such as lack of precision and inadequate therapeutic efficiency. As a medical application of nanotechnology, nanomedicine exhibits great potential for liver fibrosis diagnosis and therapy. Nanomedicine enhances imaging contrast and improves tissue penetration and cellular internalization; it simultaneously achieves targeted drug delivery, combined therapy, as well as diagnosis and therapy (i.e., theranostics). In this review, recent designs and development efforts of nanomedicine systems for the diagnosis, therapy, and theranostics of liver fibrosis are introduced. Relative to traditional methods, these nanomedicine systems generally demonstrate significant improvement in liver fibrosis treatment. Perspectives and challenges related to these nanomedicine systems translated from laboratory to clinical use are also discussed.
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影响因子：
25.7
作者：
Dulai PS;Sirlin CB;Loomba R
通讯作者：
Loomba R
影响因子：
5.8
作者：
de Carvalho, Thais Gomes;Garcia, Vinicius Barreto;de Araujo Junior, Raimundo Fernandes
通讯作者：
de Araujo Junior, Raimundo Fernandes
影响因子：
13.5
作者：
Ankoma-Sey, V;Wang, Y;Dai, ZH
通讯作者：
Dai, ZH
DOI：
10.1002/hep.27936
发表时间：
2015-10
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Jiménez Calvente C;Sehgal A;Popov Y;Kim YO;Zevallos V;Sahin U;Diken M;Schuppan D
通讯作者：
Schuppan D
影响因子：
13.3
作者：
Duong, Hien T. T.;Dong, Zhixia;Wang, Jianhua
通讯作者：
Wang, Jianhua