Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial
Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial
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DOI：
10.1097/hjh.0b013e3282b9720e
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发表时间：
2007-10-01
影响因子：
4.9
通讯作者：
Lipkowitz, Michael S.
中科院分区：
文献类型：
--
作者：
Bhatnagar, Vibha;O'Connor, Daniel T.;Lipkowitz, Michael S.
目的血管紧张素转换酶（ACE）基因分型是否能预测血管紧张素转换酶（ACE）抑制剂对血压的影响，目前尚不清楚。方法对347名非裔美国人肾脏病和高血压研究的受试者进行ACE插入/缺失多态性下游的3个多态性基因分型（Ins/ Del）：G12269A、C17888T和G20037A。达到目标平均动脉压的时间（
Objective It has yet to be determined whether genotyping at the angiotensin- converting enzyme ( ACE) locus is predictive of blood pressure response to an ACE inhibitor.Methods Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril ( n=347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/ deletion polymorphism ( Ins/ Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (