Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis.
Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis.
复制标题
幼年牙周炎中针对放线菌伴白细胞毒素的血清中和活性。
DOI：
10.1111/j.1600-051x.1981.tb02043.x
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发表时间：
1981
影响因子：
6.7
通讯作者：
Taichman,NS
中科院分区：
文献类型：
--
作者：
Tsai,CC;McArthur,WP;Baehni,PC;Evian,C;Genco,RJ;Taichman,NS
在青少年牙周炎患者的牙龈下菌斑样本中，放线菌感染的发生率相对较高。这些生物具有一种强效的白质毒素，能迅速破坏分离的人类多形核白细胞（pmn）和单核细胞。如果这些白细胞毒素在体内发挥作用，它们可能会剥夺牙龈缝隙区域必不可少的抗菌防御机制。我们发现，青少年牙周炎患者的血清中始终（约90%）含有中和放线菌和白质毒素的抗体。另一方面，正常人或患有其他类型牙周病的患者的血清通常会增强而不是抑制白细胞毒性反应。许多青少年牙周炎患者有明显的PMN或单核细胞趋化性缺陷，这可能使他们有被放线菌感染的危险。针对这些微生物的免疫反应可能是青少年牙周炎病程的关键决定因素。虽然这种疾病相对罕见，但它确实给患者及其家人带来了难以估量的情感、身体和经济困难。在这种疾病中，作为潜在病原体的放线菌双歧杆菌的鉴定可能最终导致特定形式的治疗，以预防和消除这些患者中这种有机体的感染。
A relatively high incidence of infection byActinobacillus actinomycetemcomitanscan be shown in subgingival plaque samples obtained from patients with juvenile periodontitis. These organisms possess a potent leukotoxin(s) which rapidly destroys isolated human polymorphonuclear leukocytes (PMNs) and monocytes. If such leukotoxins operatein vivo, they could deprive the gingival crevice area of an essential antibacterial defense mechanism. We have found that sera from juvenile periodontitis patients consistently (>90%) contain antibodies which neutralizeActinobacillus actinomycetemcomitansleukotoxin(s). On the other hand, sera from normal individuals or patients with other types of periodontal disease usually amplified rather than inhibited the leukotoxic reaction. Many patients with juvenile periodontitis have demonstrable defects in PMN or monocyte chemotaxis and this may place them at risk to gingival infection byActinobacillus actinomycetemcomitans.The immune response against these organisms could be a crucial determinant in the course of juvenile periodontitis. While this disease is relatively rare, it does cause immeasurable emotional, physical and economic hardship for patients and their families. The identification ofActinobacillus actinomycetemcomitansas a potential pathogen in this disorder may eventually lead to specific forms of therapy to prevent and eliminate infection by this organism in these patients.