LATENT ADENOVIRUS INFECTIONS OF THE HUMAN RESPIRATORY TRACT
LATENT ADENOVIRUS INFECTIONS OF THE HUMAN RESPIRATORY TRACT
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DOI：
10.1093/oxfordjournals.aje.a119932
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发表时间：
1958-01-01
影响因子：
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通讯作者：
EVANS, AS
中科院分区：
文献类型：
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作者：
EVANS, AS
通过在组织培养中长时间培养，从30个扁桃体中的15个、9个肺中的1个和4个纵隔淋巴结中分离出腺病毒。鉴定的腺病毒类型包括4种1型、11种2型和1种5型。隔离在6至10岁年龄组中最常见。除了一个例外，潜伏腺病毒感染患者的血清含有腺病毒的中和抗体或补体固定抗体，或两者兼而有之。通过切碎、匀浆或冻融等方法均不能直接从组织中分离出腺病毒。在试管中培养的扁桃体组织中，在组织生长17至96天后检测到腺病毒，并且病毒在最初出现后持续排泄74天。通过增加组织的数量，从植入到病毒出现的滞后期可以缩短到8天，这说明这种滞后期是由于病毒数量少而不是由于任何“掩蔽效应”。腺病毒感染的自然历史是讨论根据目前的证据。
Adenoviruses were isolated from 15 of 30 tonsils, 1 of 9 lungs, and none of 4 mediastinal lymph nodes by growing these tissues for prolonged periods in tissue culture. The adenovirus types identified include 4 type 1, 11 type 2, and 1 type 5. Isolations were most common in the 6-to-10-year age group. With one exception the serum from patients with latent adenovirus infections contained neutralizing antibodies or complement-fixing antibodies, or both, to adenovirus. Adenovirus could not be isolated from the tissues directly by mincing, homogenizing or freezing and thawing. Adenovirus was detected in tonsil tissue grown in test tubes after 17 to 96 days of tissue growth and virus excretion persisted up to 74 days after its initial appearance. The lag period from implantation to the appearance of virus could be shortened to 8 days by increasing the amount of tissue, thus suggesting that the lag period was due to a small amount of virus rather than to any "masking effect". The natural history of adenovirus infections is discussed in light of current evidence.