Preliminary results of MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer
Preliminary results of MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer
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DOI：
10.1016/j.brachy.2014.07.006
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发表时间：
2015-01-01
期刊：
影响因子：
1.9
通讯作者：
Tanaka, Eiichi
中科院分区：
文献类型：
--
作者：
Yoshida, Ken;Yamazaki, Hideya;Tanaka, Eiichi
目得：研究我们的新的MRI辅助高剂量率间质近距离放射治疗宫颈cancer.METHODS和材料的有效性：2005年6月和2009年6月之间，29名以前未经治疗的宫颈癌患者（2 T2 b，2 T3 a，19 T3 b，6 T4肿瘤）。我们使用我们独特的流动技术植入MRI兼容的塑料导管。总治疗剂量为30-36戈伊（6戈伊/次），联合外照射。结果：中位D-90（高危临床靶区）、D-2（cc）（膀胱）和D-2（cc）（直肠）/次分别为6.9、5和4.6戈伊。T2、T3和T4肿瘤的3年局部控制率分别为100%、95%和83%。4例患者发生3级或4级晚期并发症。结论：我们对基于图像的高剂量率间质性近距离放射治疗的初步评价显示了良好的局部治疗结果，并发症发生率可接受。(C)2015年美国近距离放射治疗协会。爱思唯尔公司出版All rights reserved.
PURPOSE: To investigate the effectiveness of our novel MRI-assisted high-dose-rate interstitial brachytherapy for uterine cervical cancer.METHODS AND MATERIALS: Between June 2005 and June 2009, 29 previously untreated patients with cervical cancer were enrolled (2 T2b, 2 T3a, 19 T3b, and 6 T4 tumors). We implanted MRI-compatible plastic catheters using our unique ambulatory technique. The total treatment doses were 30-36 Gy (6 Gy per fraction) combined with external beam radiotherapy.RESULTS: The median D-90 (high-risk clinical target volume), D-2 (cc) (bladder), and D-2 (cc) (rectum) per fraction were 6.9, 5, and 4.6 Gy, respectively. The 3-year local control rates were 100%, 95%, and 83% for T2, T3, and T4 tumors, respectively. Grade 3 or 4 late complications occurred in 4 patients.CONCLUSIONS: Our preliminary evaluation of image-based high-dose-rate interstitial brachytherapy showed favorable local treatment results with an acceptable complication rate. (C) 2015 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.