Aptamer-Assisted Assembly of Gold Nanoframe Dimers
Aptamer-Assisted Assembly of Gold Nanoframe Dimers
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DOI：
10.1002/ppsc.201300187
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发表时间：
2013-12-01
影响因子：
2.7
通讯作者：
Tsukruk, Vladimir V.
中科院分区：
文献类型：
--
作者：
Combs, Zachary A.;Malak, Sidney T.;Tsukruk, Vladimir V.
本文报道了纳米框架二聚体在配体功能化较小的球形金纳米粒子辅助下的组装，作为生物电子转移反应重要分子核黄素的表面增强拉曼散射（SERS）生物陷阱。在这种方法中，设计用于核黄素选择性结合的适配体包覆的金纳米颗粒也作为稀释溶液中纳米框架二聚化的静电驱动器。金纳米框架二聚体为等离子体耦合提供了独特的条件，为大体积生物分子的结合提供了足够的空间。与传统的有机配体相比，适体的使用允许高度选择性地结合目标分析物，具有一微摩尔核黄素的极低检测限。
The assembly of nanoframe dimers assisted by aptamer-functionalized smaller spherical gold nanoparticles as prospective surface-enhanced Raman scattering (SERS) biotraps for riboflavin, an important molecule for biological electron transfer reactions, is reported. In this approach, the aptamer-coated gold nanoparticles designed for selective binding of riboflavin also serve as the electrostatic driver for nanoframe dimerization in dilute solutions. The gold nanoframe dimers provide unique conditions for plasmonic coupling in a hot spot with sufficient space for the binding of bulky biomolecules. The use of an aptamer allows for highly selective binding of the targeted analyte as compared with conventional organic ligands with excellent low detection limit of one micromole of riboflavin.