HISTAMINE LEVELS IN PLASMA, BLOOD, AND URINE IN SEVERE ASTHMA, AND EFFECT OF CORTICOSTEROID TREATMENT
HISTAMINE LEVELS IN PLASMA, BLOOD, AND URINE IN SEVERE ASTHMA, AND EFFECT OF CORTICOSTEROID TREATMENT
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DOI：
10.1136/thx.31.6.724
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发表时间：
1976-01-01
期刊：
影响因子：
10
通讯作者：
TAYLOR, WH
中科院分区：
文献类型：
--
作者：
BRUCE, C;WEATHERSTONE, R;TAYLOR, WH
已测定了 64 名正常受试者、10 名严重哮喘患者和 10 名患有其他疾病的对照患者的血浆、全血和尿组胺水平。三组之间的平均全血水平没有差异。哮喘患者的平均血浆水平显着高于正常受试者，但对照组患者则不然。对照患者的尿组胺排出量低于正常人，但哮喘患者的尿组胺排出量与正常人没有差异。皮质类固醇治疗导致哮喘患者的全血组胺浓度显着下降，通常降至几乎检测不到的水平，并将血浆水平恢复至正常，但不影响尿组胺水平。
Plasma, whole blood, and urinary histamine levels have been determined in 64 normal subjects, in 10 patients with severe asthma, and in 10 control patients with other illnesses. The mean whole blood levels did not differ between the three groups. The mean plasma level in the asthmatics was significantly greater than that of the normal subjects but not of the control patients. The urinary histamine output was lower in the control patients than in the normal subjects but in the asthmatics did not differ from that of the normals. Corticosteroid therapy caused a marked fall, often to barely detectable levels, of the whole blood histamine concentration of the asthmatic patients and restored the plasma levels to normal but did not affect urinary histamine levels.