Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
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DOI：
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发表时间：
2002-07
期刊：
影响因子：
11.2
通讯作者：
M. Sanchez-Cespedes;P. Parrella;M. Esteller;S. Nomoto;B. Trink;J. Engles;W. Westra;J. Herman
中科院分区：
文献类型：
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作者：
M. Sanchez-Cespedes;P. Parrella;M. Esteller;S. Nomoto;B. Trink;J. Engles;W. Westra;J. Herman
最近在散发性肺腺癌中观察到染色体19 p的频繁丢失，靶向一个关键的肿瘤抑制基因的位置。我们对19号染色体短臂进行了精细定位，发现LKB 1/STK 11基因定位在最小缺失区。由于LKB 1/STK 11的生殖系突变导致Peutz-Jeghers综合征和癌症风险增加，我们对肺肿瘤中的LKB 1/STK 11基因进行了详细的遗传筛查。我们在原发性肺腺癌和肺癌细胞系中检测到高频率的体细胞改变（主要是无义突变）。因此，我们的研究结果首次表明，LKB 1/STK 11失活是一个非常常见的事件，并可能在散发性肺腺癌的发展整体参与。
Frequent losses of chromosome 19p have recently been observed in sporadic lung adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped in the minimal-deleted region. Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors. We detected a high frequency of somatic alterations (mainly nonsense mutations) in primary lung adenocarcinomas and in lung cancer cell lines. Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.