Aspirin in combination with TACE in treatment of unresectable HCC: a matched-pairs analysis.
Aspirin in combination with TACE in treatment of unresectable HCC: a matched-pairs analysis.
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阿司匹林联合 TACE 治疗不可切除的 HCC：配对分析。
DOI：
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Zheng-Gang Ren
中科院分区：
文献类型：
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作者：
Cheng-Dong Qin;Rong-Rong Yao;Rui Zhang;Zheng-Gang Ren
肝动脉化疗栓塞术（TACE）是治疗不能切除的肝细胞癌（HCC）的主要方法。然而，由于肿瘤进展或治疗失败，其疗效目前有限。研究表明，阿司匹林可降低包括HCC在内的多种恶性肿瘤的发病率，并与化疗在结肠癌的治疗中发挥协同作用。因此，我们旨在研究阿司匹林对接受TACE治疗的不可切除HCC患者的辅助作用。进行了回顾性配对分析，以评价阿司匹林联合TACE治疗的疗效。共入组了120例肝癌患者，其中60例接受阿司匹林治疗心血管疾病、短暂性脑缺血发作和关节炎的患者，以及60例同期未接受阿司匹林治疗的配对肝癌患者。与非阿司匹林使用者相比，接受阿司匹林治疗的患者的OS有所改善（P = 0.050）。具体而言，接受全剂量阿司匹林治疗的患者显示OS延长（P = 0.027），这是多变量分析中与OS相关的独立因素（风险比0.498，95%置信区间0.280-0.888，P = 0.018）。阿司匹林联合TACE可改善不能切除的HCC患者的OS。因此，阿司匹林对HCC患者的影响值得进一步的前瞻性研究。
Transarterial chemoembolization (TACE) is the principal therapy for unresectable hepatocellular carcinoma (HCC). However, its efficacy is currently limited owing to tumor progression or treatment failure. It has been shown that aspirin reduces the incidence of multiple malignant tumors including HCC and plays a synergistic role with chemotherapy in the treatment of colon cancer. Therefore, we aimed to investigate the adjuvant effect of aspirin on patients with unresectable HCC who underwent TACE therapy. A retrospective matched-pairs analysis was performed to evaluate the efficacy of aspirin in combination with TACE therapy. A total of 120 patients with HCC, including 60 patients treated with aspirin for treatment of cardiovascular disease, transient ischemic attack, and arthritis, and 60 paired matching HCC patients without aspirin treatment in the same period, were enrolled. Compared with non-aspirin users, patients treated with aspirin showed improved OS (P = 0.050). Specifically, patients treated with a full dose of aspirin showed prolonged OS (P = 0.027), which was an independent factor associated with OS in multivariate analysis (hazard ratio 0.498, 95% confidence interval 0.280-0.888, P = 0.018). Aspirin in combination with TACE might improve OS in patients with unresectable HCC. Thus, the impact of aspirin on patients with HCC warrants further investigation prospectively.
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作者：
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DOI：
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发表时间：
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期刊：
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