Postpartum depression in rats: Differences in swim test immobility, sucrose preference and nurturing behaviors
Postpartum depression in rats: Differences in swim test immobility, sucrose preference and nurturing behaviors
复制标题
DOI：
10.1016/j.bbr.2014.06.041
复制
发表时间：
2014-10-01
影响因子：
2.7
通讯作者：
Wecker, Lynn
中科院分区：
文献类型：
--
作者：
Fernandez, Jamie Winderbaum;Grizzell, J. Alex;Wecker, Lynn
产后抑郁症（PPD）是一种常见的疾病，影响母亲和他们的后代。在实验室动物中进行的PPD研究通常评估了激素补充和停药后或应激模型中卵巢切除大鼠在强迫游泳试验中的不动性或蔗糖偏好。到目前为止，很少有研究将这些措施与母亲的行为联系起来，这是产后抑郁样活动的潜在指标。由于单一的措施可能不足以表征抑郁症，本研究确定了抑郁样行为的分布在Sprague-Dawley大鼠产后。在产后的前12天内记录未受干扰的母鼠表现出的养育和非养育行为，此后测定了强迫游泳试验中的不动性和蔗糖偏好。中位数分裂分析表明，19%的母鼠表现出高蔗糖偏好和低不动性，30%的母鼠表现出仅高不动性或仅低蔗糖偏好，21%的母鼠表现出高不动性和低偏好。在一个或两个测试中表现出抑郁样活动的水坝在昼夜周期的黑暗阶段表现出增加的自我导向行为和减少的主动养育。这是第一项研究，以表征不受干扰的养育和非养育行为，并使用蔗糖偏好和不动性在强迫游泳试验中，对产后大鼠母鼠表现出的PPD内表型进行分类。目前的研究强调了这样一个观点，即应该使用多种测试来表征抑郁样行为，这在人类和实验室动物群体中都是高度异质性的。(C)© 2014 Elsevier B. V.保留所有权利。
Postpartum depression (PPD) is a common disorder affecting both mothers and their offspring. Studies of PPD in laboratory animals have typically assessed either immobility on forced swim testing or sucrose preference in ovariectomized rats following hormone supplementation and withdrawal or in stress models. To date, few studies have related these measures to maternal behaviors, a potential indicator of depressive-like activity postpartum. Because a single measure may be insufficient to characterize depression, the present study determined the distribution of depressive-like behaviors in Sprague-Dawley rats postpartum. Nurturing and non-nurturing behaviors exhibited by undisturbed dams were recorded during the first 12 days postpartum, and immobility in the forced swim test and sucrose preference were determined thereafter. A median-split analysis indicated that 19% of dams exhibited high sucrose preference and low immobility, 30% exhibited either only high immobility or only low sucrose preference, and 21% exhibited both high immobility and low preference. Dams exhibiting depressive-like activity on either or both tests displayed increased self-directed behaviors and decreased active nurturing during the dark phase of the diurnal cycle. This is the first study to characterize undisturbed nurturing and non-nurturing behaviors, and use both sucrose preference and immobility in the forced swim test, to classify PPD endophenotypes exhibited by rat dams following parturition. The present study underscores the idea that multiple tests should be used to characterize depressive-like behavior, which is highly heterogeneous in both the human and laboratory animal populations. (C) 2014 Elsevier B.V. All rights reserved.