Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity
Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity
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DOI：
10.1038/s41551-019-0435-y
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发表时间：
2019-08-01
影响因子：
28.1
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Bai, Wubin;Shin, Jiho;Rogers, John A.
内部生理过程的实时监测能力可以为药理学给药时间表、手术干预程序以及恢复和康复管理提供信息。目前的方法依赖于外部成像技术或植入式传感器，无法在临床相关的时间尺度上提供连续的信息，也无法满足外科手术的相关成本和风险要求。在这里，我们描述了可注射类光子器件，完全由自然吸收的材料制成，并在受控的操作寿命后从体内清除，用于目标组织和生物流体的光谱表征。作为一个应用实例，我们展示了该装置可用于连续监测大脑温度，氧合和神经活动的自由移动的老鼠。这些类型的设备应该在疾病病理学的基础研究、神经科学研究、外科手术和监测损伤或疾病的恢复方面被证明是有用的。
Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/ or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.