Obstructive sleep apnea and COVID-19 clinical outcomes during hospitalization: a cohort study
Obstructive sleep apnea and COVID-19 clinical outcomes during hospitalization: a cohort study
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DOI：
10.5664/jcsm.9424
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发表时间：
2021-11-01
影响因子：
4.3
通讯作者：
Parthasarathy, Sairam
中科院分区：
文献类型：
--
作者：
Mashaqi, Saif;Lee-Iannotti, Joyce;Parthasarathy, Sairam
研究目的：阻塞性睡眠呼吸暂停（OSA）是一种非常常见的睡眠障碍。基于与OSA和COVID-19相关的相似共病医学状况，提出了OSA和2019冠状病毒病（COVID-19）严重程度之间的潜在关联。方法：我们对2020年3月至10月期间因COVID-19住院的1，738例患者进行了回顾性分析。根据国际疾病分类（ICD; OSA和COVID-19分别编码G47.33和U07.1），根据是否存在OSA诊断对患者进行分类。收集其他数据，包括人口统计学、体重指数和合并症。使用快速COVID-19严重程度指数比较各组之间的COVID-19严重程度。结果：与无OSA的患者相比，OSA患者的快速COVID-19严重程度指数评分较高。然而，OSA组中2型糖尿病（P < .0001）、冠状动脉疾病（P < .0001）、充血性心力衰竭（P < .0001）和慢性阻塞性肺疾病（P < .0001）的患病率也显著较高。未经调整的模型显示，COVID-19和OSA患者入住重症监护室的风险更高。然而，这种关联被减弱，并在调整年龄，性别，体重指数和共病disorders.Conclusions后变得不显著：在我们的研究中，OSA似乎不是住院患者COVID-19预后恶化的独立危险因素。需要更大样本量的进一步研究来描述OSA在确定COVID-19住院患者结局方面的潜在作用。
Study Objectives: Obstructive sleep apnea (OSA) is an extremely common sleep disorder. A potential association between OSA and coronavirus disease 2019 (COVID-19) severity has been proposed on the basis of similar comorbid medical conditions associated with both OSA and COVID-19.Methods: We performed a retrospective review of 1,738 patients who were hospitalized with COVID-19 between March and October of 2020. Patients were classified based on the presence or absence of OSA diagnosis based upon the International Classification of Diseases (ICD; codes G47.33 and U07.1 for OSA and COVID-19, respectively). Other data were collected, including demographics, body mass index, and comorbid conditions. COVID-19 severity was compared between groups using the quick COVID-19 severity index.Results: Quick COVID-19 severity index scores were higher in patients with OSA compared with those without OSA. However, the prevalence rates of type 2 diabetes (P < .0001), coronary artery disease (P < .0001), congestive heart failure (P < .0001), and chronic obstructive pulmonary diseases (P < .0001) were also significantly greater in the OSA group. Unadjusted models revealed higher risk of intensive care unit admission in patients with COVID-19 and OSA. However, such an association was attenuated and became nonsignificant after adjusting for age, sex, body mass index, and comorbid disease.Conclusions: In our study, OSA does not appear to be an independent risk factor for worse COVID-19 outcomes in hospitalized patients. Further studies with larger sample sizes are needed to delineate the potential role of OSA in determining outcomes in hospitalized patients with COVID-19.