RELATIVE ROLE OF CALORIC RESTRICTION AND EXERCISE TRAINING UPON SUSCEPTIBILITY TO ISOPROTERENOL-INDUCED MYOCARDIAL-INFARCTION IN MALE-RATS
RELATIVE ROLE OF CALORIC RESTRICTION AND EXERCISE TRAINING UPON SUSCEPTIBILITY TO ISOPROTERENOL-INDUCED MYOCARDIAL-INFARCTION IN MALE-RATS
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DOI：
10.1093/ajcn/34.5.841
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发表时间：
1981-01-01
影响因子：
7.1
通讯作者：
BEITZ, DC
中科院分区：
文献类型：
--
作者：
CRANDALL, DL;FEIRER, RP;BEITZ, DC
为了确定体重和身体活动不足对药物诱导的心肌梗死的易感性的相对影响，随机选择100日龄雄性Sprague-Dawley大鼠组进行10周的运动训练和（或）热量限制程序，随后进行2次皮下注射。注射异丙肾上腺素给两组大鼠喂食由最低卡路里组成的限制性饮食以维持体重，并进行运动（R-Ex）或保持久坐（R-C），一组随意喂食并进行运动（Ex），一组保持久坐（C），但提供足够的食物以维持体重在与Ex大鼠相似的范围内。各组之间的体重没有差异，但Ex和C大鼠的最终体重显着更大。所有Ex、R-Ex和R-C大鼠在注射异丙肾上腺素后存活，但50%的C大鼠死亡。C组大鼠血浆总乳酸脱氢酶（LDH）活性显著高于R-Ex组（P < 0.05）; R-Ex和R-C大鼠的血浆LDH-1（心脏同工酶）活性显著低于体重较重的Ex和C大鼠。R-C大鼠血浆LDH-1活性显著低于Ex大鼠，表明较小的未训练大鼠的心肌损伤低于较重的运动训练大鼠。运动或维持体重有利于预防药物诱导的心肌梗死，但当体重维持与运动相结合时，可提供额外的保护。
To determine the relative effect of body weight and physical inactivity on susceptibility to drug-induced myocardial infarction, randomly selected groups of 100 day old male Sprague-Dawley rats were subjected to a 10 wk program of exercise training and (or) to caloric restriction followed by 2 s.c. injections of L-isoproterenol. Two groups of rats were fed a restricted diet consisting of minimum calories to maintain body weight and were exercised (R-Ex) or remained sedentary (R-C), 1 group was fed ad lib and subjected to exercise (Ex), and 1 group remained sedentary (C), but was provided enough food to maintain body weight in a range similar to Ex rats. There was no difference between group body weights, but Ex and C rats exhibited a significantly greater final body weight. All Ex, R-Ex and R-C rats survived the isoproterenol injections but 50% of C rats died. Group C rats exhibited significantly greater activity of total plasma lactate dehyrogenase (LDH), whereas R-Ex rats had the lowest total LDH activity (P < 0.05). R-Ex and R-C rats had a significantly lower activity of plasma LDH-1, the heart isozyme, than did the heavier Ex and C rats. R-C rats exhibited a significantly decreased amount of plasma LDH-1 activity compared with Ex-rats, indicating that smaller, untrained rats had less myocardial damage than the heavier, exercise-trained rats. Exercise or maintenance of body weight is beneficial toward prevention of the drug-induced myocardial infarction, but when weight maintenance is combined with exercise additional protection is provided.