Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo
Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo
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DOI：
10.1016/s0092-8674(00)81035-1
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发表时间：
1996-02-23
期刊：
影响因子：
64.5
通讯作者：
Zinn, K
中科院分区：
文献类型：
--
作者：
Desai, CJ;Gindhart, JG;Zinn, K
酪氨酸受体磷酸酶DPTP69D和DPTP99A在果蝇胚胎运动轴突上表达。在缺乏DPTP69D蛋白的突变胚胎中，运动神经元生长锥在到达肌肉目标之前停止生长，或者沿着不正确的途径绕过这些肌肉。缺乏DPTP99A的突变胚胎与野生型无法区分。然而，dptp69D - dptp99A双突变胚胎的运动轴突缺陷比仅缺乏dptp69D的胚胎严重得多。我们的研究结果表明，DPTP69D和DPTP99A是运动轴突引导所必需的，并且它们在神经肌肉系统的发育过程中具有部分冗余功能。
The receptor tyrosine phosphatases DPTP69D and DPTP99A are expressed on motor axons in Drosophila embryos. In mutant embryos lacking DPTP69D protein, motor neuron growth cones stop growing before reaching their muscle targets, or follow incorrect pathways that bypass these muscles. Mutant embryos lacking DPTP99A are indistinguishable from wild type. Motor axon defects in dptp69D dptp99A double mutant embryos, however, are much more severe than in embryos lacking only DPTP69D. Our results demonstrate that DPTP69D and DPTP99A are required for motor axon guidance and that they have partially redundant functions during development of the neuromuscular system.