Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
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DOI：
10.1016/j.schres.2010.01.014
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发表时间：
2010-05-01
影响因子：
4.5
通讯作者：
Ozaki, Norio
中科院分区：
文献类型：
--
作者：
Aleksic, Branko;Kushima, Itaru;Ozaki, Norio
本研究的目的是检查日本受试者中两个wnt通路相关基因KREMEN1和DKK 1与精神分裂症的关联。我们对上述基因中的16种常见遗传变异进行了基因分型，并研究了它们与精神分裂症的关系。结果表明，在KREMEN1的启动子区域的一个共同的变异可能会调节精神分裂症的风险在日本。然而，将需要进一步的复制，以决定性的解释这个位点对精神分裂症的发病机制的影响。(C)2010 Elsevier B.V.保留所有权利。
The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.