A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy.
A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy.
复制标题
DOI：
10.3390/cancers13061356
复制
发表时间：
2021-03-17
期刊：
影响因子：
5.2
通讯作者：
Shimokawa T
中科院分区：
文献类型：
--
作者：
Prezado Y;Hirayama R;Matsufuji N;Inaniwa T;Martínez-Rovira I;Seksek O;Bertho A;Koike S;Labiod D;Pouzoulet F;Polledo L;Warfving N;Liens A;Bergs J;Shimokawa T
低氧肿瘤的治疗仍然是放射治疗的主要挑战之一。微束放射治疗（MBRT）显示出在正常组织中非常有希望的毒性降低，使得具有极高LET的非常重的离子（例如氖（Ne）或氩（Ar））可能适用于临床情况。靶中的高LET对于克服缺氧将是无与伦比的，而MBRT可能会限制通常阻止在常规辐射环境中使用这些重离子的副作用。在这份手稿中报告的工作是显着减少正常组织（皮肤）的毒性后Ne MBRT照射相比，传统的Ne照射的第一个实验证明。这一结果可能使重离子在癌症治疗中的新用途成为可能。 (1)背景资料：在所有类型的辐射中，非常重的离子，例如氖（Ne）或氩（Ar），由于其降低的氧增强效应，是低氧肿瘤治疗的最佳候选物。然而，由于严重的副作用，它们在20世纪70年代的开创性临床使用被停止。本工作的目的是提供第一个证据，即超重离子与微束放射治疗的组合导致毒性最小化，从而打开了大门，重新使用重离子治疗;（2）方法：无论是Ne MBRT或Ne宽束照射小鼠腿部在相同的平均剂量。皮肤毒性评分持续四周。结果：两组间的毒性差异有统计学意义（P < 0. 05）。宽束照射组出现严重损伤，包括坏死，而MBRT组仅出现轻度至轻度红斑;（4）结论：Ne MBRT的耐受性明显优于传统宽束照射。
The treatment of hypoxic tumours continues to be one of the main challenges for radiation therapy. Minibeam radiation therapy (MBRT) shows a highly promising reduction of to-xicity in normal tissue, so that very heavy ions, such as Neon (Ne) or Argon (Ar), with extremely high LET, might become applicable to clinical situations. The high LET in the target would be unrivalled to overcome hypoxia, while MBRT might limit the side effects normally preventing the use of those heavy ions in a conventional radiotherapeutic setting. The work reported in this manuscript is the first experimental proof of the remarkable reduction of normal tissue (skin) toxicities after Ne MBRT irradiations as compared to conventional Ne irradiations. This result might allow for a renewed use of very heavy ions for cancer therapy. (1) Background: among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhancement effect. However, their pioneering clinical use in the 1970s was halted due to severe side effects. The aim of this work was to provide a first proof that the combination of very heavy ions with minibeam radiation therapy leads to a minimization of toxicities and, thus, opening the door for a renewed use of heavy ions for therapy; (2) Methods: mouse legs were irradiated with either Ne MBRT or Ne broad beams at the same average dose. Skin toxicity was scored for a period of four weeks. Histopathology evaluations were carried out at the end of the study; (3) Results: a significant difference in toxicity was observed between the two irradiated groups. While severe da-mage, including necrosis, was observed in the broad beam group, only light to mild erythema was present in the MBRT group; (4) Conclusion: Ne MBRT is significantly better tolerated than conventional broad beam irradiations.
登录
查看更多内容
DOI：
10.1073/pnas.0505020102
发表时间：
2005-10-04
影响因子：
11.1
作者：
Belyakov, OV;Mitchell, SA;Brenner, DJ
通讯作者：
Brenner, DJ
影响因子：
3.8
作者：
Gonzalez, W.;Prezadoa, Y.
通讯作者：
Prezadoa, Y.
DOI：
10.1016/0360-3016(77)90235-8
发表时间：
1977-01-01
影响因子：
7
作者：
LEITH, JT;WOODRUFF, KH;LEWINSKY, BS
通讯作者：
LEWINSKY, BS
影响因子：
8
作者：
Graham K;Unger E
通讯作者：
Unger E
DOI：
10.1016/0360-3016(94)90550-9
发表时间：
1994-07-01
影响因子：
7
作者：
CASTRO, JR;LINSTADT, DE;PHILLIPS, TL
通讯作者：
PHILLIPS, TL