Polydopamine coated Au-Pt nanorods: Enhanced photothermal properties and efficient reactive oxygen scavengers
Polydopamine coated Au-Pt nanorods: Enhanced photothermal properties and efficient reactive oxygen scavengers
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DOI：
10.1016/j.colsurfb.2021.112247
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发表时间：
2021-11-30
影响因子：
5.8
通讯作者：
Sang, Shengbo
中科院分区：
文献类型：
--
作者：
Duan, Qianqian;Wang, Jialin;Sang, Shengbo
光热疗法（Photothermal Therapy，PTT）作为一种新兴的肿瘤治疗策略，具有精确、可控、微创、低成本、毒副作用小等优点，近年来受到广泛关注。具有独特局域表面等离子体共振（LSPR）效应的贵金属纳米材料特别适合作为光热转换剂，但目前开发的贵金属纳米光热转换剂存在合成工艺复杂、光热性能差、生物毒性大等问题。此外，PTT治疗过程中产生的大量活性氧（ROS）可能对肿瘤周围的健康组织造成不可逆的损伤。在这项工作中，我们将铂（Pt）沉积在金纳米棒（AuNRs）的尖端，形成哑铃形的Au-Pt纳米棒（AuPtNRs），并与生物相容性聚多巴胺（PDA）功能化AuPtNRs，得到AuPt@PDA。在808 nm激光照射下，AuPt@PDA具有良好的光热稳定性，其光热转换效率（PCE）达到81.78%，明显高于AuNRs（52.32%）和AuPtNRs（78.76%）。AuPt@PDA具有较低的细胞毒性，在体外对癌细胞进行PTT后，使细胞存活率从91.12%降至39.36%，同时显著降低热应激产生的细胞内ROS水平。因此，AuPt@PDA在PTT中的优异光热性质、高癌细胞杀伤和ROS清除活性可能是改善治疗功效同时降低由于热应激诱导的ROS形成而引起的毒副作用的风险的理想候选物。
As an emerging cancer treatment strategy, photothermal therapy (PTT) is precise, controllable, minimally invasive, low cost and less toxic side effects, thus photothermal transduction agents have been extensively investigated in recent years. Noble metal nanomaterials with unique localized surface plasmon resonance (LSPR) effects are particularly suitable as photothermal transduction agent, but the currently developed precious noble metal nano photothermal transduction agents face serious problems such as complex synthesis process, poor photothermal performance and high biotoxicity. Moreover, the large amount of reactive oxygen species (ROS) produced during PTT treatment could cause irreversible damage to the healthy tissues surrounding the tumor. In this work, we deposited platinum (Pt) on the tips of gold nanorods (AuNRs) to form dumbbell-shaped Au-Pt bimetallic nanorods (AuPtNRs), and functionalized AuPtNRs with biocompatible polydopamine (PDA) to obtain AuPt@PDA. With 808 nm laser irradiation, the prepared AuPt@PDA exhibited excellent photothermal stability, and its photothermal conversion efficiency (PCE) reached 81.78%, which was significantly higher than that of AuNRs (52.32%) and AuPtNRs (78.76%). With low cytotoxicity, AuPt@PDA decreased cell viability from 91.12% to 39.36% after PTT on cancer cells in vitro, while significantly reducing intracellular ROS levels generated by heat stress. Therefore, the excellent photothermal properties, high cancer cell killing and ROS scavenging activity of AuPt@PDA in PTT could be an ideal candidate for improving therapeutic efficacy while reducing the risk of toxic side effects due to heat stress-induced ROS formation.