Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?
Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?
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DOI：
10.1093/ofid/ofw166
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发表时间：
2016-06-01
影响因子：
4.2
通讯作者：
Garcia-Sherman, Melissa C.
中科院分区：
文献类型：
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作者：
Klotz, Stephen A.;Sobonya, Richard E.;Garcia-Sherman, Melissa C.
令人惊讶的是，深部真菌病侵袭的患者组织通常缺乏炎症反应的证据。这种宿主反应的缺乏通常归因于继发于化疗的中性粒细胞减少症。然而，系统的研究并不支持这种简单化的解释。然而，侵袭性真菌病变的特征在于丰富的真菌功能性淀粉样蛋白，其反过来又被血清淀粉样蛋白P组分（SAP）结合。我们推测SAP在侵袭性真菌感染的局部免疫应答中是重要的。真菌功能性淀粉样蛋白，SAP，和深部真菌病的免疫反应之间的相互作用进行了讨论。
It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn is bound by serum amyloid P component (SAP). We postulate that SAP is important in the local immune response in invasive fungal infections. The interaction between fungal functional amyloid, SAP, and the immune response in deep mycoses is discussed.