TISSUE-SPECIFIC MODULATION OF THE MITOCHONDRIAL CALCIUM UNIPORTER BY MAGNESIUM-IONS
TISSUE-SPECIFIC MODULATION OF THE MITOCHONDRIAL CALCIUM UNIPORTER BY MAGNESIUM-IONS
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DOI：
10.1016/0014-5793(85)80789-4
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发表时间：
1985-01-01
期刊：
影响因子：
3.5
通讯作者：
BERNARDI, P
中科院分区：
文献类型：
--
作者：
FAVARON, M;BERNARDI, P
本文分析了大鼠心脏、肾脏和肝脏线粒体Ca2+单转运体在Ca2+浓度接近稳态值（1-4μM）范围内的运行动力学。心脏线粒体表现出最低的活性，生理Mg2+浓度抑制线粒体Ca2+单转运蛋白大约。50%在心脏和肾脏，20%在肝脏。在生理Ca2+和Mg2+浓度下，体外呼吸线粒体维持的游离Ca2+在心脏和肾脏中的含量高于肝脏线粒体。这种行为可能代表了不同线粒体对其特定细胞内环境的适应。
This paper analyzes the kinetics of the Ca2+uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca2+concentrations near the steady-state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg2+concentrations inhibit the mitochondrial Ca2+uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca2+and Mg2+concentrations the external free Ca2+maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.