Brain grey matter deficits in smokers: focus on the cerebellum
Brain grey matter deficits in smokers: focus on the cerebellum
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DOI：
10.1007/s00429-011-0346-5
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发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Gallinat, Juergen
中科院分区：
文献类型：
--
作者：
Kuehn, Simone;Romanowski, Alexander;Gallinat, Juergen
吸烟者的结构性脑缺陷通过对皮质和皮质下结构的形态计量学研究得到了很好的表征。尽管小脑在精神和成瘾障碍中的作用越来越受到关注，但还没有关于吸烟者采用专门设计的方法评估小脑形态的小脑变化的报告。我们获得了33名重度吸烟者和22名从不吸烟者的高分辨率MRI扫描，并使用了基于体素的形态测量(VBM)方法，利用空间无偏幕下(Suit)工具箱(Diedrichsen 2006)提供了与吸烟相关的小脑结构变化的优化和细粒度探索。与从不吸烟的人相比，吸烟者右侧小脑I小脑灰质体积显著减少。根据Fagerstrom量表评估，小脑I小脑灰质体积与尼古丁依赖程度呈负相关。由于CRU I已被确认为小脑的认知分区，结构性缺陷可能在一定程度上调节了先前报道的吸烟者的认知缺陷。值得注意的是，与依赖相关的体积缺陷的大小可能支持小脑实质上参与药物依赖的核心机制的概念。
Structural cerebral deficiencies in smokers have been well characterized by morphometric investigations focussing on cortical and subcortical structures. Although the role of the cerebellum is increasingly noted in mental and addiction disorders, no reports exist regarding cerebellar alterations in smokers employing a methodology specifically designed to assess the cerebellar morphology. We acquired high-resolution MRI scans from 33 heavy smokers and 22 never-smokers and used a voxel-based morphometry (VBM) approach utilizing the Spatially Unbiased Infratentorial (SUIT) toolbox (Diedrichsen 2006) to provide an optimized and fine-grained exploration of cerebellar structural alterations associated with smoking. Relative to never-smokers, smokers showed significant reductions of grey matter volume in the right cerebellum Crus I. The grey matter volume in Crus I correlated negatively with the amount of nicotine dependence as assessed by means of the Fagerstrom scale. Since Crus I has been identified as the cognitive division of the cerebellum, the structural deficit may in part mediate cognitive deficits previously reported in smokers. Of note, the dependence-related magnitude of the volume deficit may support the notion that the cerebellum is substantially involved in core mechanisms of drug dependence.