Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion.
Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion.
复制标题
慢性尼古丁输注可减轻压力引发的血浆醛固酮升高。
DOI：
10.1016/j.ejphar.2004.05.030
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sabban,EstherL
中科院分区：
文献类型：
--
作者：
StierJr,CharlesT;Serova,LidiaI;Singh,Gagan;Sabban,EstherL
The ability of nicotine infusion to modulate plasma aldosterone levels in response to different stressors was investigated. Sprague–Dawley rats given nicotine (5 mg/kg/day) or saline for 14 days were subjected to stress. Baseline plasma aldosterone (86±17 pmol/l) was unaffected by nicotine. Aldosterone was significantly elevated by restraint (450±72 pmol/l) and especially with cold (1249±172 pmol/l) or immobilization (1779±247 pmol/l) stress. Nicotine infusion attenuated the rise in aldosterone with restraint and cold stress, but not immobilization. These results reveal that nicotine infusion can attenuate the aldosterone response, depending on the type of stress.
