XMRV Discovery and Prostate Cancer-Related Research.
XMRV Discovery and Prostate Cancer-Related Research.
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DOI：
10.1155/2011/432837
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发表时间：
2011
影响因子：
2.2
通讯作者：
Silverman RH
中科院分区：
文献类型：
--
作者：
Kang DE;Lee MC;Das Gupta J;Klein EA;Silverman RH
异嗜性小鼠白血病病毒相关病毒(XMRV)于2006年在一项对具有抗病毒酶RNaseL基因变异的人类前列腺癌患者的研究中首次报告。随后在北美、欧洲、亚洲和非洲的研究发现或未能在患者(前列腺癌、慢性疲劳综合征-肌痛性脑脊髓炎(CFS-ME)和免疫抑制伴呼吸道感染)或正常、健康的对照组中检测到XMRV。主要的混杂因素是实验室中几乎无处不在的鼠源性试剂、抗体和细胞，通常还有XMRV本身。XMRV在许多人类细胞系中感染和复制良好，特别是在某些前列腺癌细胞系中。在非人类灵长类动物感染模型中，XMRV也向前列腺传播。在这里，我们将回顾XMRV的发现，然后重点介绍与这种耐人寻味的病毒有关的前列腺癌相关研究。
Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories. XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus.