Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets.
Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets.
复制标题
DOI：
10.1016/j.tibtech.2016.08.002
复制
发表时间：
2017-02
影响因子：
17.3
通讯作者：
C. Rüter;M. A. Schmidt
中科院分区：
文献类型：
--
作者：
C. Rüter;M. A. Schmidt
细菌病原体已经开发出了有趣的毒力机制，包括几种复杂的纳米机器，用于注射效应蛋白来操纵宿主免疫信号通路以获得自身利益。因此，细菌基因组中包含了大量关于如何操纵宿主防御系统的信息。目前的理解主要是将毒力机制作为抗菌剂的靶标。我们提出了一个范式的变化，利用细菌效应不作为目标，但作为工具，直接操纵主机信号-为主机的利益。最近，已经鉴定了自主易位到宿主细胞中的效应蛋白，代表了一类新的细胞穿透肽（CPP）或效应物（CPE）。此外，自主细胞渗透通过将特定治疗剂转导至细胞内靶点来克服药理学中的一个主要障碍。
Bacterial pathogens have developed intriguing virulence mechanisms, including several sophisticated nanomachines, for injecting effector proteins to manipulate host immune signaling pathways for their own benefit. Therefore, bacterial genomes harbor a wealth of information about how to manipulate the defense systems of the host. Current understanding addresses virulence mechanisms mostly as targets for antimicrobials. We propose a change of paradigm by exploiting bacterial effectors not as targets but as tools for the directed manipulation of host signaling – for the benefit of the host. Recently, effector proteins have been identified that autonomously translocate into host cells, representing a novel class of cell-penetrating peptides (CPPs) or effectors (CPEs). Moreover, autonomous cell penetration overcomes a major hurdle in pharmacology by transducing specific therapeutic agents to intracellular targets.