Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation.
Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation.
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DOI：
10.1038/s41598-021-91510-x
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发表时间：
2021-06-10
影响因子：
4.6
通讯作者：
Degens H
中科院分区：
文献类型：
--
作者：
Darabseh MZ;Maden-Wilkinson TM;Welbourne G;Wüst RCI;Ahmed N;Aushah H;Selfe J;Morse CI;Degens H
吸烟对呼吸和骨骼肌功能有负面影响，是各种慢性病的危险因素。为了评估戒烟14天对人类呼吸和骨骼肌功能、炎症和氧化应激标志物的影响。对38名不吸烟者和48名吸烟者在戒烟前和戒烟14天后的肺活量、骨骼肌功能、循环碳氧血红蛋白水平、晚期糖基化终产物(AGEs)、氧化应激标志物和血清细胞因子进行了检测。吸烟者的最大呼气流量(p = 0.004)和用力呼气容积/用力肺活量(p = 0.037)低于非吸烟者，但戒烟后无明显变化。戒烟提高了骨骼肌的疲劳抵抗力(p <； 0.001)。吸烟者的血红蛋白含量、红细胞压积、碳氧血红蛋白、总AGE、丙二醛、肿瘤坏死因子-α、IL-2、IL-4、IL-6和IL-10水平较高(p 和lt； )，而总抗氧化状态、IL-12p70和嗜酸性粒细胞数较低(p 和lt； 0.05)。IL-4、IL-6、IL-10和IL-12p70在戒烟14天后已恢复到非吸烟者的水平(p <； 0.05)，IL-2和α也表现出类似的模式，但尚未完全恢复到非吸烟者的水平。随着戒烟时间的延长，血红蛋白、红细胞压积、嗜酸性粒细胞计数、AGEs、MDA和TAS无明显变化。戒烟两周后，吸烟者的肌肉疲劳抵抗力有所提高，轻度全身炎症也有所减少。
Cigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.
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DOI：
10.1034/j.1600-0773.2003.930306.x
发表时间：
2003-09-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
Alonso, JR;Cardellach, F;Miró, O
通讯作者：
Miró, O
影响因子：
17.3
作者：
AITCHISON, R;RUSSELL, N
通讯作者：
RUSSELL, N
DOI：
10.1164/rccm.201410-1830pp
发表时间：
2015-03-15
影响因子：
24.7
作者：
Degens, Hans;Gayan-Ramirez, Ghislaine;van Hees, Hieronymus W. H.
通讯作者：
van Hees, Hieronymus W. H.
影响因子：
4.8
作者：
Biemel, KM;Friedl, DA;Lederer, MO
通讯作者：
Lederer, MO
影响因子：
5.8
作者：
Braber S;Henricks PA;Nijkamp FP;Kraneveld AD;Folkerts G
通讯作者：
Folkerts G