Oxytocin receptor genotype and low economic privilege reverses ventral striatum-social anxiety association
Oxytocin receptor genotype and low economic privilege reverses ventral striatum-social anxiety association
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DOI：
10.1080/17470919.2017.1403954
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发表时间：
2019-01-02
影响因子：
2
通讯作者：
Connelly, Jessica J.
中科院分区：
文献类型：
--
作者：
Gonzalez, Marlen Z.;Puglia, Meghan H.;Connelly, Jessica J.
催产素受体基因（OXTR）多态性、下腹侧纹状体（VS）对社会刺激的反应和较低的经济特权与抑郁和焦虑独立相关。然而，这些危险因素之间的相互作用尚不清楚。157名基因为OXTR rs237915的健康成人参与者在功能磁共振成像期间完成了一项常见的情绪匹配任务。通过有效的自我报告方法同时评估过去的经济特权和抑郁和焦虑症状。结果表明，rs237915基因型与经济特权对消极面孔的神经反应存在交互作用。随着经济特权的增加，c -携带者的VS激活减少，VS与腹内侧前额叶皮层之间的连通性增加。TT纯合子表现出相反的模式。对负面面孔的低VS反应预示着社交焦虑的增加，但这只适用于那些经济特权较低或C等位基因的人。对于那些两者都有的人来说，低VS反应与较低的社交焦虑有关。研究结果表明，经济特权和OXTR rs237915基因型可能会对社会动机神经系统产生好坏影响。虽然对负面面孔的低VS反应通常可能构成社交焦虑的风险因素，但对社交线索的低反应可能对具有双重风险的人有益。
Oxytocin receptor gene (OXTR) polymorphisms, lower ventral striatum (VS) response to social stimuli, and lower economic privilege have been independently associated with depression and anxiety. However, the interactions between these risk factors are unknown. One hundred and fifty-seven healthy adult participants genotyped for OXTR rs237915 completed a common emotion-matching task during functional magnetic resonance imaging. Past economic privilege and depression and anxiety symptoms were concurrently assessed through validated self-report measures. The data revealed an interaction between rs237915 genotype and economic privilege on the neural response to negative faces. C-carriers showed decreased VS activation and increased connectivity between the VS and ventromedial prefrontal cortex with increased economic privilege. TT homozygotes showed the reverse pattern. Low VS response to negative faces predicted increased social anxiety, but only for those with either lower economic privilege or the C allele. For those with both, low VS response was associated with paradoxically lower social anxiety. Findings suggest that economic privilege and OXTR rs237915 genotype may calibrate social motivational neural systems for better or worse. While lower VS response to negative faces may generally constitute a risk factor for social anxiety, lower response to social cues may be a benefit for those with dual risk.