HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection.
HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection.
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DOI：
10.1086/605695
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发表时间：
2009-10
期刊：
影响因子：
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通讯作者：
Michael Santosuosso;E. Righi;V. Lindstrom;P. Leblanc;M. Poznansky
中科院分区：
文献类型：
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作者：
Michael Santosuosso;E. Righi;V. Lindstrom;P. Leblanc;M. Poznansky
人类免疫缺陷病毒1型（HIV-1）的包膜蛋白糖蛋白120 （gp120）已被证明在体外失调T细胞功能。我们获得了慢性HIV-1感染个体的尸检组织，以确定淋巴组织和/或血液中是否有足够的gp120来引发这些效应。我们发现gp120在其中一些个体的脾脏和淋巴结中以高浓度（约300 pg/mL）存在。相比之下，在所有测试的血清样本中检测到极低量的gp120和p24。这些发现支持了gp120的非进入功能和人类免疫缺陷病毒（HIV）诱导的免疫失调的慢性性质的临床相关性。
The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects. We found that gp120 was present in high concentrations (>300 pg/mL) in the spleen and lymph nodes of some of these individuals. In contrast, very low amounts of gp120 and p24 were detected in all serum samples tested. These findings underpin the clinical relevance of nonentry functions of gp120 and the chronic nature of human immunodeficiency virus (HIV)-induced immune dysregulation.