Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection
Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection
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DOI：
10.1128/jvi.78.20.11411-11415.2004
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发表时间：
2004-10-01
影响因子：
5.4
通讯作者：
Zafiropoulos, A
中科院分区：
文献类型：
--
作者：
Everett, RD;Zafiropoulos, A
在单纯疱疹病毒1型(HSV-1)感染过程中，ND10结构被病毒调节蛋白ICP0破坏。这种作用的重要性仍然存在争议，部分原因是有报道称，主要的ND10早幼粒细胞白血病(PML)蛋白的高水平表达阻止了ND10的破坏，但不能抑制HSV-1感染。在这里，我们展示了在HSV-1感染期间ND10的戏剧性重组，即使在PML过表达的情况下也是如此。
ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.