Mammalian Cell Survival Responses after Exposure to Elevated Temperatures
Mammalian Cell Survival Responses after Exposure to Elevated Temperatures
复制标题
暴露于高温后哺乳动物细胞的生存反应
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
G. Hahn
中科院分区：
文献类型：
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作者：
G. Hahn
当前癌症治疗的概念集中于杀死肿瘤细胞。在手术的情况下，这是通过切除和物理去除癌组织来实现的。放射和药物治疗需要使绝大多数个体恶性细胞原位失活。这必须在不损害正常组织的情况下进行，以免其功能永久受损。对于许多正常组织，如骨髓、皮肤和胃肠道内壁，功能水平在很大程度上取决于在放射或药物治疗结束时保持生殖完整性的干细胞的数量。由于所有这些原因，暴露于热的恶性和正常细胞的生存动力学非常重要。在培养细胞上进行实验比在体内细胞上进行实验要容易得多，尽管此类研究对癌症研究的贡献当然取决于它们预测体内细胞群行为的能力。从历史上看，在热效应研究中，组织培养研究享有相当独特的地位。很大程度上正是此类研究的结果引起了当前的临床兴趣，而不是像放疗和化疗那样相反。
Current concepts of cancer treatment focus on the killing of neoplastic cells. In the case of surgery this is accomplished by excision and physical removal of the cancerous tissue. Radiation and drug treatments require the inactivation in situ of the vast majority of individual malignant cells. This must be done without damaging normal tissue to the point where its function is permanently compromised. For many normal tissues such as bone marrow, skin, and the lining of the gastrointestinal tract, functional level is largely determined by the number of stem cells that have maintained reproductive integrity at the end of the radiation or drug treatment. For all of these reasons, the survival kinetics of malignant and normal cells exposed to heat are of considerable importance. Experiments are much easier to perform on cultured cells than on cells in vivo, although of course the contribution to cancer research of such investigations depends on their ability to predict behavior of cell populations in vivo. Historically, in research on heat effects the tissue culture studies enjoy a rather unique position. It is largely the results of such studies that have fanned the current clinical interest, not the reverse, as tended to be the case with radiotherapy and chemotherapy.