GAMETOCYTE FORMATION BY THE PROGENY OF SINGLE PLASMODIUM-FALCIPARUM SCHIZONTS
GAMETOCYTE FORMATION BY THE PROGENY OF SINGLE PLASMODIUM-FALCIPARUM SCHIZONTS
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DOI：
10.2307/3281374
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发表时间：
1983-01-01
影响因子：
1.3
通讯作者：
INSELBURG, J
中科院分区：
文献类型：
--
作者：
INSELBURG, J
研究了疟原虫恶性疟原虫在组织培养皿上单层红细胞的配子细胞发生。单个分裂体在覆盖单层的红细胞中产生的分裂子感染了附着的红细胞，并产生了后代群。在这些容易识别的群集中，寄生虫要么经历无性生长，要么经历有性分化。大多数分裂体的后代不产生配子体。那些产生配子体的分裂体的后代显示出产生多个配子体的明显趋势。配子细胞发生不是随机的。相反，某些分裂体的后代致力于产生配子。然而，即使那些包含几个配子体的簇也包含无性形式。并非单个分裂体的所有分裂子都进行配子体发生。在那些被2个或更多的分裂子感染的细胞中，配子体的形成通常与其他寄生虫进一步发育的阻碍有关。
Gametocytogenesis of the malaria parasite P. falciparum was studied in monolayers of erythrocytes attached to tissue culture dishes. Merozoites produced by single schizonts in erythrocytes [from humans] overlaying the monolayer infected the attached erythrocytes and produced clusters of progeny. Parasites in these readily indentifiable clusters than underwent either asexual growth or sexual differentiation. The progeny of most schizonts yeilded no gametocytes. The progeny of those schizonts that did yield gametocytes showed a marked tendency to produce multiple gametocytes. Gametocytogenesis was not random. Instead, the progeny of certain schizonts were committed to produce gametes. However, even those clusters containing several gametocytes also contained asexual forms. Not all merozoites of a single schizont were committed to gametocytogenesis. In those cells infected with 2 or more merozoites the formation of a gametocyte was usually associated with a block in the further development of other parasites.