Neurons of the peripheral nervous system express thymidine phosphorylase
Neurons of the peripheral nervous system express thymidine phosphorylase
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DOI：
10.1016/0304-3940(95)11622-4
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发表时间：
1995-06
影响因子：
2.5
通讯作者：
P. Eccleston;K. Funa;C. Heldin
中科院分区：
文献类型：
--
作者：
P. Eccleston;K. Funa;C. Heldin
血小板衍生内皮细胞生长因子（PD-ECGF）是一种血管生成因子，最近已被证明是相同的胸苷磷酸化酶。我们在这里描述，高水平的表达PD-ECGF/胸苷磷酸化酶在周围神经系统（PNS）的神经元，但很少在中枢神经系统（CNS）。用单克隆和多克隆抗体对背根神经节、颈交感神经节、肠神经丛以及脑和脊髓的切片进行染色。此外，原位杂交证实了免疫组织化学的结果。胸苷磷酸化酶在PNS中的可能作用进行了讨论。
Platelet-derived endothelial cell growth factor (PD-ECGF) is an angiogenic factor which recently has been shown to be identical to thymidine phosphorylase. We describe here, high levels of expression of PD-ECGF/thymidine phosphorylase in neurons of the peripheral nervous system (PNS) but very little in the central nervous system (CNS). Monoclonal and polyclonal antibodies were used for the staining of sections of dorsal root ganglia, sympathetic cervical ganglia and the enteric plexus as well as the brain and spinal cord. In addition, in situ hybridisation confirmed the results of immunohistochemistry. The possible role of thymidine phosphorylase in the PNS is discussed.