Updates in the Diagnosis of Intraductal Neoplasms of the Pancreas.

Updates in the Diagnosis of Intraductal Neoplasms of the Pancreas.
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DOI:
10.3389/fphys.2022.856803
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发表时间:
2022
影响因子:
4
通讯作者:
Shi J
Shi J
中科院分区:
医学2区
文献类型:
--
作者:
Assarzadegan N;Babaniamansour S;Shi J

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胰腺导管腺癌(PDAC)是世界上最致命的癌症之一。这种令人沮丧的预后有很多原因,包括诊断时的晚期和缺乏有效的治疗方法。导管内乳头状粘液性肿瘤(IPMN)是可检测和可治疗的PDAC前驱病变。在过去的几十年里,我们对IPMNs病理学的理解不断发展,诊断工具也出现了新的进展。新的世界卫生组织(WHO)分类方案现在将以前考虑的IPMN变体,如导管内嗜酸性乳头状肿瘤(IOPN)和导管内小管乳头状肿瘤(ITPN),视为不同的肿瘤。正在开发新的成像和分子诊断测试,以更好地识别这些PDAC前体病变。在这里,我们回顾了IPMN,IOPN和ITPN诊断工具的进展,强调了新的(第5版,2019年)WHO病理诊断分类,分子标记物,新的实验室检查和成像工具。
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer worldwide. There are many reasons for this dismal prognosis, including the advanced stage at the time of diagnosis and the lack of effective therapeutic approaches. Intraductal papillary mucinous neoplasms (IPMNs) represent detectable and treatable precursor lesions of PDAC. Our understanding of the pathology of IPMNs has evolved over the past few decades, and new advances in diagnostic tools have emerged. The new World Health Organization (WHO) classification scheme now recognizes the previously considered variants of IPMNs, such as intraductal oncocytic papillary neoplasms (IOPNs) and intraductal tubulopapillary neoplasms (ITPNs), as distinct neoplasms. New imaging and molecular diagnostic tests are being developed to recognize these PDAC precursor lesions better. Here, we review the advances in diagnostic tools for IPMNs, IOPNs, and ITPNs, emphasizing the new (5th edition, 2019) WHO classification for pathological diagnosis, molecular markers, new laboratory tests, and imaging tools.
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