A new formula for calculating standard liver volume for living donor liver transplantation without using body weight
A new formula for calculating standard liver volume for living donor liver transplantation without using body weight
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DOI：
10.1016/j.jhep.2015.05.026
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发表时间：
2015-10-01
影响因子：
25.7
通讯作者：
Halkic, Nermin
中科院分区：
文献类型：
--
作者：
Kokudo, Takashi;Hasegawa, Kiyoshi;Halkic, Nermin
背景与目的：标准肝体积（SLV）在肝脏外科，尤其是活体肝移植（LDLT）中应用广泛。所有报道的公式SLV使用体表面积或体重，这可能会受到强烈的影响，由一般条件的patient.Methods：我们分析了180名日本供体候选人和160名瑞士患者的肝脏体积正常的肝脏开发一个新的公式。数据集被随机分为两个子集，测试和验证样本，按种族分层。新的公式进行了验证，使用50 LDLT recipies.Results：不使用体重相关的变量，年龄，胸部宽度测量使用计算机断层扫描，和种族独立预测的总肝体积（TLV）。新公式：203.3 -（3.61 x年龄）+（58.7 x胸宽）-（463.7 +/-人种[1 =亚洲人，0 =高加索人]），与任何其他公式相比，最准确地预测了验证数据集中的TLV。LDLT的移植物体积与术后凝血酶原时间相关，使用新公式计算的移植物体积/SLV比值与术后凝血酶原时间的相关性明显优于使用其他公式计算的移植物体积/SLV比值或移植物体积/体重比值。使用年龄、胸宽和种族推导出的新公式比之前报道的任何其他公式更准确地预测了健康患者组的TLV和LDLT接受者的SLV。(C)2015年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background & Aims: The standard liver volume (SLV) is widely used in liver surgery, especially for living donor liver transplantation (LDLT). All the reported formulas for SLV use body surface area or body weight, which can be influenced strongly by the general condition of the patient.Methods: We analyzed the liver volumes of 180 Japanese donor candidates and 160 Swiss patients with normal livers to develop a new formula. The dataset was randomly divided into two subsets, the test and validation sample, stratified by race. The new formula was validated using 50 LDLT recipients.Results: Without using body weight-related variables, age, thoracic width measured using computed tomography, and race independently predicted the total liver volume (TLV). A new formula: 203.3 - (3.61 x age) + (58.7 x thoracic width) - (463.7 +/- race [1 = Asian, 0 = Caucasian]), most accurately predicted the TLV in the validation dataset as compared with any other formulas. The graft volume for LDLT was correlated with the postoperative prothrombin time, and the graft volume/SLV ratio calculated using the new formula was significantly better correlated with the postoperative prothrombin time than the graft volume/SLV ratio calculated using the other formulas or the graft volume/body weight ratio.Conclusions: The new formula derived using the age, thoracic width and race predicted both the TLV in the healthy patient group and the SLV in LDLT recipients more accurately than any other previously reported formulas. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.