The identification of cerebral volume changes in treated growth hormone-deficient adults using serial 3D MR image processing
The identification of cerebral volume changes in treated growth hormone-deficient adults using serial 3D MR image processing
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DOI：
10.1097/00004728-200001000-00025
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发表时间：
2000-01-01
影响因子：
1.3
通讯作者：
Hill, DLG
中科院分区：
文献类型：
--
作者：
Denton, ERE;Holden, M;Hill, DLG
目的：一个试点研究，以检测生长激素（GH）缺乏的成年人用GH治疗的体积变化，使用串行3D MR图像处理，并评估是否需要分割之前registrationwered.Method：体积MR扫描的大脑中获得5例患者和6个对照组。患者在治疗前和治疗后3个月和6个月进行扫描。对照组受试者以相同的时间间隔进行扫描。使用体模来量化缩放误差。通过最大化归一化互信息将第二和第三体积与基线对齐，并使用正弦插值进行转换。在有和没有脑分割和缩放误差校正的情况下进行配准。每个配准的变换图像都减去原始图像，生成差异图像。对原始图像和差分图像的结构变化以及分割和缩放误差校正的效果进行了评估。结果：与对照组相比，GH治疗组脑容量增加，脑室容量减少（p = 0.91 × 10 ~（-3））。尺度校正和分割没有差异（p = 1和p = 0.873）。在差异图像中识别出结构变化，但在原始图像中未识别出结构变化（p = 0.136）。放射科医生检测到的变化>200 μ m结论：GH治疗缺陷患者的脑体积变化可通过系列MR研究的配准和减影检测到，但不能通过标准的图像评估。这种配准方法不需要预先分割。
Purpose: A pilot study to detect volume changes of cerebral structures in growth hormone (GH)-deficient adults treated with GH using serial 3D MR image processing and to assess need for segmentation prior to registration was conducted.Method: Volume MR scans of the brain were obtained in five patients and six control subjects. Patients were scanned before and after 3 and 6 months of therapy. Control subjects were scanned at the same intervals. A phantom was used to quantify scaling errors. Second and third volumes were aligned with the baseline by maximizing normalized mutual information and transformed using sine interpolation. Registration was performed with and without brain segmentation and correction of scaling errors. Each registered, transformed image had the original subtracted, generating a difference image. Structural change and effects of segmentation and scaling error correction were assessed on original and difference images. The radiologists' ability to detect volume change was also assessed.Results: Compared with control subjects, GH-treated subjects had an increase in cerebral volume and reduction in ventricular volume (p = 0.91 x 10(-3)). Scale correction and segmentation made no difference (p = 1 and p = 0.873). Structural changes were identified in the difference images but not in the original (p = 0.136). The radiologists detected changes >200 mu mConclusion: GH treatment in deficient patients results in cerebral volume changes detectable by registration and subtraction of serial MR studies but not by standard assessment of images. This registration method did not require prior segmentation.