The glucocorticoid receptor is required for stress erythropoiesis
The glucocorticoid receptor is required for stress erythropoiesis
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DOI：
10.1101/gad.13.22.2996
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发表时间：
1999-11-15
影响因子：
10.5
通讯作者：
Beug, H
中科院分区：
文献类型：
--
作者：
Bauer, A;Tronche, F;Beug, H
糖皮质激素受体（GR）在体内协调多种生理反应。在体外，糖皮质激素是红细胞祖细胞（ebls）持续增殖所必需的。在这里，我们分析了GR对活体红细胞生成的影响，使用GR缺陷小鼠或表达GR缺陷的小鼠进行反激活。体外，原代ebls的持续增殖需要完整的GR。在体内，在红细胞溶解或缺氧等应激情况下，ebls的快速扩张需要GR。一种特殊的，对gr敏感的祖细胞可以被确定为对应激反应负责。因此，gr介导的ebl增殖调控对体内应激性红细胞生成至关重要。
The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vive, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained proliferation of primary ebls requires an intact GR. In vive, the GR is required for rapid expansion of ebls under stress situations like erythrolysis or hypoxia. A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo.