Effects of Exposure to 5.8 GHz Electromagnetic Field on Micronucleus Formation, DNA Strand Breaks, and Heat Shock Protein Expressions in Cells Derived From Human Eye
Effects of Exposure to 5.8 GHz Electromagnetic Field on Micronucleus Formation, DNA Strand Breaks, and Heat Shock Protein Expressions in Cells Derived From Human Eye
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DOI：
10.1109/tnb.2019.2905491
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发表时间：
2019-04-01
影响因子：
3.9
通讯作者：
Shinohara, Naoki
中科院分区：
文献类型：
--
作者：
Miyakoshi, Junji;Tonomura, Hiroshi;Shinohara, Naoki
在不久的将来，重型汽车和乘用车将引入电气化。然而，无线电能传输(WPT)对能量的要求很高，必须评估各种类型的WPT系统的适用性。本文描述了一种解决与该技术相关的技术和安全问题的方法。我们将人眼角膜上皮(HCE-T)细胞暴露于5.8 GHz电磁场中24小时，我们观察到暴露于1 mW/cm(2)(ICNIRP中的一般公共水平)的5.8 GHz电磁场中的细胞微核率与假暴露或孵箱对照组相比没有统计学意义上的显著增加。同样，DNA链断裂，热休克蛋白(HSP)Hsp27、Hsp70和Hsp90α的表达也没有表现出统计上的显著影响。这些结果表明，1 mW/cm(2)5.8 GHz电磁场作用24 h对人眼细胞微核形成、DNA链断裂和热休克蛋白表达的影响很小或没有影响。
In the near future, electrification will be introduced to heavy-duty vehicles and passenger cars. However, the wireless power transfer (WPT) requires high energy levels, and the suitability of various types of WPT systems must be assessed. This paper describes a method for solving technical and safety issues associated with this technology. We exposed human corneal epithelial (HCE-T) cells derived from the human eye to 5.8-GHz electromagnetic fields for 24 h. We observed no statistically significant increase in micronucleus (MN) frequency in cells exposed to a 5.8-GHz field at 1 mW/cm(2) (the general public level in ICNIRP) relative to sham-exposed or incubator controls. Similarly, the DNA strand breaks, and the expression of heat shock protein (Hsp) Hsp27, Hsp70, and Hsp90 alpha exhibited no statistically significant effects as a result of exposure. These results indicate that the exposure to 5.8-GHz electromagnetic fields at 1 mW/cm(2) for 24 h has little or no effect on micronucleus formation, DNA strand breaks, and Hsp expression in human eye cells.