CDART: Protein homology by domain architecture
CDART: Protein homology by domain architecture
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DOI：
10.1101/gr.278202
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发表时间：
2002-10-01
期刊：
影响因子：
7
通讯作者：
Bryant, SH
中科院分区：
文献类型：
--
作者：
Geer, LY;Domrachev, M;Bryant, SH
保守结构域结构检索工具（CDART）基于结构域结构（定义为蛋白质中保守结构域的顺序）对NCBl Protein Database进行相似性搜索。该算法使用敏感的蛋白质结构域谱而不是直接序列相似性来发现跨越显著进化距离的蛋白质相似性。与查询蛋白质相似的蛋白质按结构分组并评分。依赖于域配置文件允许CDART是快速的，并且，因为它依赖于注释的功能域，信息丰富。域配置文件是从包含功能注释的多个域定义集合中派生出来的。可以通过分类法和选择感兴趣的域来进一步细化分类。CDART可在http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi上获得。
The Conserved Domain Architecture Retrieval Tool (CDART) performs similarity searches of the NCBl Entrez Protein Database based on domain architecture, defined as the sequential order of conserved domains in proteins. The algorithm finds protein similarities across significant evolutionary distances using sensitive protein domain profiles rather than by direct sequence similarity. Proteins similar to a query protein are grouped and scored by architecture. Relying on domain profiles allows CDART to be fast, and, because it relies on annotated functional domains, informative. Domain profiles are derived from several collections of domain definitions that include functional annotation. Searches can be further refined by taxonomy and by selecting domains of interest. CDART is available at http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi.