Molecular cartography of the human skin surface in 3D
Molecular cartography of the human skin surface in 3D
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DOI：
10.1073/pnas.1424409112
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发表时间：
2015-04-28
影响因子：
11.1
通讯作者：
Dorrestein, Pieter C.
中科院分区：
文献类型：
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作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
人体皮肤是一个表面积为 1.5-2 m(2) 的器官，为我们提供与环境的界面。该器官的分子组成来源于宿主细胞、微生物群和外部分子。皮肤表面的化学成分很大程度上是不确定的。在这里，我们利用质谱数据和微生物 16S rRNA 扩增子序列的 3D 绘图，推进探索皮肤分子的拓扑分布所需的技术。我们的 3D 地图显示，皮肤的分子成分具有不同的分布，并且该成分不仅由皮肤细胞和微生物决定，还由我们的日常生活（包括卫生产品的使用）决定。这些地图的技术发展为研究人类皮肤与卫生、微生物群和环境的空间关系奠定了基础，并有可能开发适合个人健康的皮肤表型预测模型。
The human skin is an organ with a surface area of 1.5-2 m(2) that provides our interface with the environment. The molecular composition of this organ is derived from host cells, microbiota, and external molecules. The chemical makeup of the skin surface is largely undefined. Here we advance the technologies needed to explore the topographical distribution of skin molecules, using 3D mapping of mass spectrometry data and microbial 16S rRNA amplicon sequences. Our 3D maps reveal that the molecular composition of skin has diverse distributions and that the composition is defined not only by skin cells and microbes but also by our daily routines, including the application of hygiene products. The technological development of these maps lays a foundation for studying the spatial relationships of human skin with hygiene, the microbiota, and environment, with potential for developing predictive models of skin phenotypes tailored to individual health.