Variation of cats under domestication: genetic assignment of domestic cats to breeds and worldwide random-bred populations
Variation of cats under domestication: genetic assignment of domestic cats to breeds and worldwide random-bred populations
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DOI：
10.1111/age.12008
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发表时间：
2013-06-01
期刊：
影响因子：
2.4
通讯作者：
Lyons, L. A.
中科院分区：
文献类型：
--
作者：
Kurushima, J. D.;Lipinski, M. J.;Lyons, L. A.
猫的饲养者和普通大众都对他们宠物的起源感兴趣，不仅对纯种个体的遗传特性感兴趣，而且对普通家猫的历史起源感兴趣。猫的喜好是一个相对较新的机构，其4050个品种中有超过85%是在过去75年中才出现的，主要是通过单基因美学特征的选择。短，但激烈的猫品种的历史构成了一个重大的挑战，以遗传标记为基础的品种识别策略的发展。采用不同的品种分配策略和方法，477猫代表29个花式重复序列，148个基因间和5个表型单核苷酸多态性分析。结果表明，Paetkau的频率论方法（单核苷酸多态性=0.78，短串联重复序列=0.88）优于Rannala和山的贝叶斯方法（单核苷酸多态性=0.56，短串联重复序列=0.83）的准确分配的个人正确的品种。此外，分配后验证步骤与五个表型的单核苷酸多态性准确地确定了0.31和0.58之间的误分配的个人提高分配的灵敏度与频率论方法的单核苷酸多态性和短串联重复序列分别为0.89和0.92。这项研究提供了一种新的多步分配策略，并建议，尽管他们的短品种历史和品种的家庭分组，大多数猫可以分配到其适当的品种或人口的起源，即种族。
Both cat breeders and the lay public have interests in the origins of their pets, not only in the genetic identity of the purebred individuals, but also in the historical origins of common household cats. The cat fancy is a relatively new institution with over 85% of its 4050 breeds arising only in the past 75years, primarily through selection on single-gene aesthetic traits. The short, yet intense cat breed history poses a significant challenge to the development of a genetic markerbased breed identification strategy. Using different breed assignment strategies and methods, 477 cats representing 29 fancy breeds were analysed with 38 short tandem repeats, 148 intergenic and five phenotypic single nucleotide polymorphisms. Results suggest the frequentist method of Paetkau (single nucleotide polymorphisms=0.78, short tandem repeats=0.88) surpasses the Bayesian method of Rannala and Mountain (single nucleotide polymorphisms=0.56, short tandem repeats=0.83) for accurate assignment of individuals to the correct breed. Additionally, a post-assignment verification step with the five phenotypic single nucleotide polymorphisms accurately identified between 0.31 and 0.58 of the misassigned individuals raising the sensitivity of assignment with the frequentist method to 0.89 and 0.92 for single nucleotide polymorphisms and short tandem repeats respectively. This study provides a novel multistep assignment strategy and suggests that, despite their short breed history and breed family groupings, a majority of cats can be assigned to their proper breed or population of origin, that is, race.