ECCENTRIC EXERCISE-INDUCED INJURY TO RAT SKELETAL-MUSCLE
ECCENTRIC EXERCISE-INDUCED INJURY TO RAT SKELETAL-MUSCLE
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DOI：
10.1152/jappl.1983.54.1.80
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
SCHWANE, JA
中科院分区：
文献类型：
--
作者：
ARMSTRONG, RB;OGILVIE, RW;SCHWANE, JA
研究了偏心率运动引起的大鼠骨骼肌病变。在0度的跑步机上跑步对肌肉的影响。倾斜（同心和偏心收缩的幅度相似），下降16度。倾斜（主要是偏心收缩）和上升16度。倾斜（主要是同心收缩）在16米。通过运动后生理伸肌血浆肌酸激酶和乳酸脱氢酶活性、葡萄糖-6-磷酸脱氢酶（g -6- pase）活性（生物化学和组织化学）以及肌肉组织学外观的变化来评估min-1和90min。尽管所有的运动方案都导致血浆酶在跑步后立即升高，但只有偏心运动在运动后1.5-2天引起后期升高。肌肉g -6- pase活性的显著增加，总是与单个核细胞的积累有关，总是在下坡和上坡跑步后1-3天出现在每个伸肌组的一些肌肉中，而在水平跑步后没有出现；上坡跑者肌肉活动的增加幅度通常低于下坡跑者；位于深层的、以慢抽搐为主的肌肉在上下跑中受到的影响最大。肌肉组织学显示，运动后一些纤维的正常带状模式被局部破坏，运动后24小时，反重力组深层慢肌间质和一些（< 5%）肌纤维中巨噬细胞积聚。虽然偏心运动显然会对肌肉造成更大的伤害，但问题仍然存在。
Skeletal muscle pathology resulting from eccentric-biased exercise in rats was studied. The effects on the muscles of running on a treadmill on a 0.degree. incline (similar amounts of concentric and eccentric contractions), down a 16.degree. incline (primarily eccentric contractions) and up a 16.degree. incline (primarily concentric contractions) at 16 m .cntdot. min-1 for 90 min were assessed by following postexercise changes in plasma creatine kinase and lactate dehydrogenase activities, glucose-6-phosphate dehydrogenase (G-6-PDase) activity (bio- and histochemically) in the physiological extensor muscles, and histological appearance of the muscles. Whereas all exercise protocols resulted in elevations of plasma enzymes immediately after running, only eccentric exercise caused late phase elevations 1.5-2 days postexercise. Significant increases in muscle G-6-PDase activity, which were always associated with accumulations of mononuclear cells, always occurred within some muscles of each extensor group 1-3 days following downhill and uphill running and did not occur following level running; the increases in activity were usually of lower magnitude in the muscles of uphill runners than in those of downhill runners; the deeply located, predominantly slow-twitch muscles were most affected by both down- and uphill running. Muscle histology demonstrated localized disruption of normal banding patterns of some fibers immediately after exercise and accumulations of macrophages in the interstitium and in some (< 5%) muscle fibers by 24 h postexercise in the deep slow muscles of the antigravity groups. Although eccentric exercise apparently causes greater injury to the muscles, questions remain.