Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.
Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.
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纤维化疾病和癌症相关成纤维细胞中的转化生长因子-β 信号转导
DOI：
10.3390/biom10121666
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发表时间：
2020-12-12
期刊：
影响因子：
5.5
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Shi X;Young CD;Zhou H;Wang X
转化生长因子-β (TGF-β)信号在胚胎发育和维持正常体内平衡中至关重要。大量证据表明，TGF-β活化作用于多种细胞类型，包括上皮细胞、成纤维细胞和免疫细胞，形成促纤维化环境，最终导致纤维化疾病。TGF-β以潜伏形式储存在基质中；一旦被激活，它促进成纤维细胞向肌成纤维细胞的转变，并调节纤维化过程中细胞外基质（ECM）的形成和重塑。TGF-β信号也可以通过其对肿瘤微环境的影响来促进癌症的进展。在癌症中，TGF-β有助于产生与癌症相关的成纤维细胞（CAFs），这些成纤维细胞与活化的或纤维化的成纤维细胞具有不同的分子和细胞特性。CAFs通过TGF-β信号传导促进肿瘤进展和慢性肿瘤纤维化。纤维化和caf介导的癌症进展有几个共同的特征，并且密切相关。在这篇综述中，我们考虑TGF-β如何促进纤维化和cafc介导的癌症进展。我们还讨论了最近的证据表明TGF-β抑制可以防御纤维化疾病或caff介导的癌症进展，以强调TGF-β靶向治疗纤维化和癌症的潜在意义。
Transforming growth factor-β (TGF-β) signaling is essential in embryo development and maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on several cell types, including epithelial cells, fibroblasts, and immune cells, to form a pro-fibrotic environment, ultimately leading to fibrotic diseases. TGF-β is stored in the matrix in a latent form; once activated, it promotes a fibroblast to myofibroblast transition and regulates extracellular matrix (ECM) formation and remodeling in fibrosis. TGF-β signaling can also promote cancer progression through its effects on the tumor microenvironment. In cancer, TGF-β contributes to the generation of cancer-associated fibroblasts (CAFs) that have different molecular and cellular properties from activated or fibrotic fibroblasts. CAFs promote tumor progression and chronic tumor fibrosis via TGF-β signaling. Fibrosis and CAF-mediated cancer progression share several common traits and are closely related. In this review, we consider how TGF-β promotes fibrosis and CAF-mediated cancer progression. We also discuss recent evidence suggesting TGF-β inhibition as a defense against fibrotic disorders or CAF-mediated cancer progression to highlight the potential implications of TGF-β-targeted therapies for fibrosis and cancer.
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TGF-β诱导的静止介导了鳞状细胞癌中肿瘤传播细胞的化学抗性。
影响因子：
23.9
作者：
Brown JA;Yonekubo Y;Hanson N;Sastre-Perona A;Basin A;Rytlewski JA;Dolgalev I;Meehan S;Tsirigos A;Beronja S;Schober M
通讯作者：
Schober M
DOI：
10.1146/annurev-pathol-052016-100322
发表时间：
2017-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Affo S;Yu LX;Schwabe RF
通讯作者：
Schwabe RF
影响因子：
50.3
作者：
Calon A;Espinet E;Palomo-Ponce S;Tauriello DV;Iglesias M;Céspedes MV;Sevillano M;Nadal C;Jung P;Zhang XH;Byrom D;Riera A;Rossell D;Mangues R;Massagué J;Sancho E;Batlle E
通讯作者：
Batlle E
影响因子：
5.6
作者：
Caja L;Dituri F;Mancarella S;Caballero-Diaz D;Moustakas A;Giannelli G;Fabregat I
通讯作者：
Fabregat I
影响因子：
6
作者：
Alvira, Cristina M.;Guignabert, Christophe;Rabinovitch, Marlene
通讯作者：
Rabinovitch, Marlene