Alterations in the limbic/paralimbic cortices of Parkinson's disease patients with hyposmia under resting-state functional MRI by regional homogeneity and functional connectivity analysis
Alterations in the limbic/paralimbic cortices of Parkinson's disease patients with hyposmia under resting-state functional MRI by regional homogeneity and functional connectivity analysis
复制标题
通过区域同质性和功能连接分析，静息态功能 MRI 下帕金森病嗅觉减退患者边缘/旁边缘皮质的变化
DOI：
10.1016/j.parkreldis.2015.04.006
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发表时间：
2015-07-01
影响因子：
4.1
通讯作者：
Cheng, Oumei
中科院分区：
文献类型：
--
作者：
Su, Meilan;Wang, Song;Cheng, Oumei
背景：嗅觉减退是帕金森病（PD）的主要早期症状，但其病理生理机制尚不清楚。静息状态功能性MRI（RS-fMRI）显示自发神经元活动。我们假设，将有嗅觉相关区域的边缘/边缘皮层在PD患者明显嗅觉减退RS-fMRI。方法：我们使用了“五种气味的嗅觉检测阵列”测试嗅觉检测（TOD）的阈值为54 PD患者和22个年龄匹配的对照。根据对照组的平均TOD将患者分为两组：PD伴明显嗅觉减退组（OH-PD，n = 38）和PD伴无/不太明显嗅觉减退组（NOH-PD，n = 16）。结果：OH-PD组和NOH-PD组边缘/边缘皮层的ReHo值不同，NOH-PD组的ReHo值与正常对照组相比差异有统计学意义。OH-PD患者部分传统嗅觉中枢（如杏仁核、嗅回、眶额皮质、海马旁回和小脑）和非传统嗅觉中枢（如直肠回和上级颞极）的ReHo显著降低，而左侧前/后扣带回的ReHo显著升高。FC分析显示边缘/边缘皮层的功能连接性下降，特别是在区域减少ReHo在OH-PD group.Conclusions：PD与嗅觉减退是相关的改变功能活动不仅在传统的嗅觉中心，但也在一些非传统的嗅觉区域的边缘/边缘皮层。(C)2015爱思唯尔有限公司版权所有。
Background: Hyposmia is a cardinal early symptom of Parkinson's disease (PD), but the pathophysiological mechanisms underlying it remain unclear. Resting-state functional MRI (RS-fMRI) demonstrates spontaneous neuronal activity. We hypothesized that there would be alterations in the olfaction-related regions of the limbic/paralimbic cortices in PD patients with obvious hyposmia by RS-fMRI.Methods: We used the "Five Odors for Olfactory Detection Arrays" to test the threshold of olfactory detection (TOD) for 54 PD patients and 22 age-matched controls. Using the mean TOD of the control group, patients were subdivided into two groups: PD with obvious hyposmia (OH-PD, n = 38) and PD with none/less obvious hyposmia (NOH-PD, n = 16). The regional brain activity of all subjects was investigated using RS-fMRI, in combination with regional homogeneity (ReHo) and functional connectivity (FC) analysis.Results: There were different ReHo values in the limbic/paralimbic cortices between the OH-PD and NOH-PD groups. ReHo was significantly decreased in OH-PD patients in parts of the traditional olfactory regions (e.g. the amygdala, olfactory gyrus, orbital frontal cortex, parahippocampal gyrus and insula) and some non-traditional olfactory centers (e.g. the rectal gyrus and superior temporal pole), while increased in the left anterior/posterior cingulate cortex. FC analysis revealed decreased functional connectivity within the limbic/paralimbic cortices, especially in regions with reduced ReHo in the OH-PD group.Conclusions: PD with hyposmia is related to altered functional activity not only in the traditional olfactory center, but also in some non-traditional olfactory regions of the limbic/paralimbic cortices. (C) 2015 Elsevier Ltd. All rights reserved.