Linear Summation Underlies Direction Selectivity in Drosophila.
Linear Summation Underlies Direction Selectivity in Drosophila.
复制标题
线性求和是果蝇方向选择性的基础。
DOI：
10.1016/j.neuron.2018.07.005
复制
发表时间：
2018
期刊：
影响因子：
16.2
通讯作者：
Clandinin,ThomasR
中科院分区：
文献类型：
--
作者：
Wienecke,CarlFR;Leong,JonathanCS;Clandinin,ThomasR
虽然线性机制为许多大脑区域的特征选择性奠定了基础，但果蝇基本运动检测器 (EMD) 中的方向选择性已成为非线性神经元计算的范例。我们通过证明线性空间求和可以在果蝇果蝇中产生方向选择性来弥合这一鸿沟。利用线性系统分析和基因编码电压指示器的双光子成像，我们测量了果蝇OFF通路中方向选择性（DS）电压信号的出现。我们的研究是对方向信号基础算法的直接定量研究，令人震惊的发现是线性空间求和足以出现方向选择性。果蝇 EMD 的线性阶段与脊椎动物视觉皮层中的类似计算非常相似，需要重新评估上游非线性的作用，并暗示该系统中特征选择性细化中的电压-钙变换。视频摘要
While linear mechanisms lay the foundations of feature selectivity in many brain areas, direction selectivity in the elementary motion detector (EMD) of the fly has become a paradigm of nonlinear neuronal computation. We have bridged this divide by demonstrating that linear spatial summation can generate direction selectivity in the fruit flyDrosophila. Using linear systems analysis and two-photon imaging of a genetically encoded voltage indicator, we measure the emergence of direction-selective (DS) voltage signals in theDrosophilaOFF pathway. Our study is a direct, quantitative investigation of the algorithm underlying directional signals, with the striking finding that linear spatial summation is sufficient for the emergence of direction selectivity. A linear stage of the fly EMD strongly resembles similar computations in vertebrate visual cortex, demands a reappraisal of the role of upstream nonlinearities, and implicates the voltage-to-calcium transformation in the refinement of feature selectivity in this system.Video Abstract