The Lateralization of Intrinsic Networks in the Aging Brain Implicates the Effects of Cognitive Training.
The Lateralization of Intrinsic Networks in the Aging Brain Implicates the Effects of Cognitive Training.
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衰老大脑中内在网络的偏侧化暗示了认知训练的影响
DOI：
10.3389/fnagi.2016.00032
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发表时间：
2016
影响因子：
4.8
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Luo C;Zhang X;Cao X;Gan Y;Li T;Cheng Y;Cao W;Jiang L;Yao D;Li C
功能偏侧化是人类大脑的一种重要组织形式。静息态大脑中固有网络的分布与认知功能、性别和年龄密切相关。在这项研究中，采用为期1年的纵向设计来评估认知训练对健康老年人固有网络偏侧化的影响。受试者被随机分为两组：一组进行为期3个月的多领域认知训练，另一组作为等待列表对照组。在训练前和训练1年后采集静息态功能磁共振成像（fMRI）数据。我们分析了10个常见静息态fMRI网络中的功能偏侧化。我们观察到对与高级认知相关的两个重要静息态网络（RSNs）——右侧和左侧额顶网络（FPNs）的偏侧化有显著的训练效果。左侧额顶网络的偏侧化在训练组中保持得特别好，但在对照组中下降。在小脑网络（CereN）中观察到随着年龄增长偏侧化增加的情况，其中对照组的偏侧化显著增加，尽管在训练组中也观察到了相同的变化趋势。这些发现表明，高级认知固有网络的偏侧化对多领域认知训练敏感。这项研究提供了神经影像学证据，支持认知训练在预防健康老年人认知衰退方面具有优势这一假设。
Lateralization of function is an important organization of the human brain. The distribution of intrinsic networks in the resting brain is strongly related to cognitive function, gender and age. In this study, a longitudinal design with 1 year’s duration was used to evaluate the cognitive training effects on the lateralization of intrinsic networks among healthy older adults. The subjects were divided into two groups randomly: one with multi-domain cognitive training over 3 months and the other as a wait-list control group. Resting state fMRI data were acquired before training and 1 year after training. We analyzed the functional lateralization in 10 common resting state fMRI networks. We observed statically significant training effects on the lateralization of two important RSNs related to high-level cognition: right- and left- frontoparietal networks (FPNs). The lateralization of the left-FPN was retained especially well in the training group but decreased in the control group. The increased lateralization with aging was observed in the cerebellum network (CereN), in which the lateralization was significantly increased in the control group, although the same change tendency was observed in the training group. These findings indicate that the lateralization of the high-level cognitive intrinsic networks is sensitive to multi-domain cognitive training. This study provides neuroimaging evidence to support the hypothesis that cognitive training should have an advantage in preventing cognitive decline in healthy older adults.