Expression of the TCL1 Gene at 14q32 in B‐Cell Malignancies but Not in Adult T‐Cell Leukemia
Expression of the TCL1 Gene at 14q32 in B‐Cell Malignancies but Not in Adult T‐Cell Leukemia
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TCL1 基因在 B 细胞恶性肿瘤中 14q32 处表达，但在成人 T 细胞白血病中不表达
DOI：
10.1111/j.1349-7006.1998.tb03275.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
M. Seto
中科院分区：
文献类型：
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作者：
J. Takizawa;R. Suzuki;H. Kuroda;A. Utsunomiya;Y. Kagami;Tatsuro Joh;Y. Aizawa;R. Ueda;M. Seto
TCL1基因最近被克隆为在T细胞恶性肿瘤中观察到的14q32.1断点簇区的候选靶点。我们检测了21例成人T细胞白血病(ATL)患者和5个细胞系的TCL1基因的表达，因为ATL被报道有频繁的14号染色体带q32异常。然而，在Northern印迹分析中，20例ATL患者和所有5个细胞株都没有TCL1的表达，仅有1例患者的TCL1转录本非常微弱。将我们的分析扩展到包括其他类型的血液系统恶性肿瘤，发现TCL1基因在除骨髓瘤之外的几乎所有B细胞系的肿瘤细胞中都有强烈的表达。然而，在T细胞或髓系细胞中未发现TCL1信号。在正常人组织中，TCL1表达于脾、淋巴结和外周血中的B淋巴细胞。这些结果表明，TCL1不是ATL的主要靶基因，但它可能在B细胞的分化和增殖中起作用。
The TCL1 gene was recently cloned as a candidate target within the 14q32.1 breakpoint cluster region observed in T‐cell malignancies. We examined the TCL1 gene expression in 21 patients with adult T‐cell leukemia (ATL) and 5 cell lines, because ATL is reported to have frequent chromosome 14 band q32 aberrations. However, 20 of the ATL patients and all 5 cell lines lacked any TCL1 expression on northern blot analysis, and TCL1 transcripts were only very faintly detected in the remaining one patient. Expansion of our analysis to include other types of hematopoietic malignancies revealed strong expression of the TCL1 gene in almost all tumor cells of B‐cell lineage except myelomas. However, no TCL1 signals were encountered in cells of T‐cell or myeloid lineages. In normal human tissues TCL1 was found to be expressed in the spleen, lymph nodes and B‐lymphocytes of peripheral blood. These results indicate that TCL1 is not a major target gene for ATL, but that it may play a role in B‐cell differentiation and proliferation.
TCL1 在成人 T 细胞白血病患者中过度表达。
DOI：
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发表时间：
1997
期刊：
Cancer research.
影响因子：
--
作者：
Narducci,MG;Stoppacciaro,A;Imada,K;Uchiyama,T;Virgilio,L;Lazzeri,C;Croce,CM;Russo,G
通讯作者：
Russo,G
t(11;14)(q13;q32) 易位淋巴恶性肿瘤中 PRAD1 的基因重排和过度表达。
影响因子：
8
作者：
Seto,M;Yamamoto,K;Iida,S;Akao,Y;Utsumi,KR;Kubonishi,I;Miyoshi,I;Ohtsuki,T;Yawata,Y;Namba,M
通讯作者：
Namba,M